SCHEMBL29384149

SCHEMBL29384149

c1cnc2[nH]c(-c3n[nH]c4ncccc34)nc2c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 4/20 0.49
FLT1 P17948 4/20 0.49
WNT1 P04628 3/20 0.43
CLK2 P49760 3/20 0.43
DYRK1A Q13627 3/20 0.43
CLK3 P49761 2/20 0.43
TGFBR1 P36897 1/20 0.43
PDPK1 O15530 4/20 0.42
ITK Q08881 2/20 0.39
CHEK1 O14757 3/20 0.39
NPC1 O15118 2/20 0.37
ALDH1A1 P00352 2/20 0.37
RAB9A P51151 2/20 0.37
LMNA P02545 1/20 0.37
GAA P10253 1/20 0.37
HTT P42858 1/20 0.37
HIF1A Q16665 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
AURKA O14965 2/20 0.36
JAK2 O60674 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17557500 1.00 FGFR1 (0.49) FGFR1FLT1WNT1CLK2DYRK1A
SCHEMBL3535294 0.87 FGFR1 (0.68) FGFR1FLT1WNT1CLK2DYRK1A
SCHEMBL29714871 0.87 FGFR1 (0.68) FGFR1FLT1WNT1CLK2DYRK1A
SCHEMBL4038255 0.87 FGFR1 (0.68) FGFR1FLT1WNT1CLK2DYRK1A
SCHEMBL17555908 0.81 CLK2 (0.50) FGFR1FLT1WNT1CLK2DYRK1A
SCHEMBL12369819 0.81 CLK2 (0.55) FGFR1FLT1WNT1CLK2DYRK1A
SCHEMBL29714866 0.81 CLK2 (0.50) FGFR1FLT1WNT1CLK2DYRK1A
SCHEMBL29833911 0.81 CLK2 (0.53) FGFR1FLT1WNT1CLK2DYRK1A
SCHEMBL17555609 0.81 CLK2 (0.53) FGFR1FLT1WNT1CLK2DYRK1A
SCHEMBL17557432 0.81 WNT1 (0.54) WNT1CLK2DYRK1ACLK3TGFBR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4031214-B1 INJECTION SYSTEMS MEIRAGTX OCULAR UK LTD (GB) 2026-02-18 EP disclosed
CN-114728132-B Injection system and method of use thereof 梅里特斯英国第二有限公司 2025-03-25 CN disclosed
EP-4196196-A1 MOTORIZED INJECTION SYSTEM AND METHODS OF USE Meiragtx UK II Limited (GB) 2023-06-21 EP disclosed
EP-4031214-A1 INJECTION SYSTEMS AND METHODS OF THEIR USE Bullseye Therapeutics, Inc. (US) 2022-07-27 EP disclosed
WO-2022036256-A1 MOTORIZED INJECTION SYSTEM AND METHODS OF USE BULLSEYE THERAPEUTICS, INC. (US) 2022-02-17 WO disclosed