Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.68 |
| ▸ | FLT1 | P17948 | 3/20 | 0.68 |
| ▸ | CLK2 | P49760 | 2/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.58 |
| ▸ | WNT1 | P04628 | 1/20 | 0.58 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.58 |
| ▸ | CLK3 | P49761 | 1/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | METAP2 | P50579 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17557500 | 0.87 | FGFR1 (0.49) | FGFR1FLT1CLK2DYRK1AWNT1 | |
| SCHEMBL29384149 | 0.87 | FGFR1 (0.49) | FGFR1FLT1CLK2DYRK1AWNT1 | |
| SCHEMBL12369819 | 0.86 | CLK2 (0.55) | FGFR1FLT1CLK2DYRK1AWNT1 | |
| SCHEMBL29714866 | 0.86 | CLK2 (0.50) | FGFR1FLT1CLK2DYRK1AWNT1 | |
| SCHEMBL17555908 | 0.86 | CLK2 (0.50) | FGFR1FLT1CLK2DYRK1AWNT1 | |
| SCHEMBL3535294 | 0.83 | FGFR1 (0.68) | FGFR1FLT1CLK2DYRK1AWNT1 | |
| SCHEMBL29714871 | 0.83 | FGFR1 (0.68) | FGFR1FLT1CLK2DYRK1AWNT1 | |
| SCHEMBL311148 | 0.82 | FGFR1 (1.00) | FGFR1FLT1CLK2DYRK1AWNT1 | |
| SCHEMBL29714859 | 0.82 | FGFR1 (1.00) | FGFR1FLT1CLK2DYRK1AWNT1 | |
| SCHEMBL4038389 | 0.81 | CLK2 (0.68) | FGFR1FLT1CLK2DYRK1AWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110190290-A1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | EPITHERIX, LLC (US) | 2011-08-04 | — | — | US | disclosed |
| US-7541367-B2 | 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-06-02 | — | — | US | disclosed |
| US-20090048249-A1 | 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-02-19 | — | — | US | disclosed |
| WO-2006130673-A1 | 3-BENZOIMIDAZOLYL-PYRAZOLOPYRIDINES USEFUL IN TREATING KINASE DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190290-A1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | BRCA1, THPO, PDXK | FGFR1 1304/4885FLT1 985/4885CLK2 2380/4885 |
| US-20090048249-A1 | 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders | PRKDC, PRKACA, ABL1 | FGFR1 508/4885FLT1 860/4885CLK2 303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.