Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 8/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CISD1 | Q9NZ45 | 5/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.47 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22499583 | 1.00 | MAPT (0.57) | MAPTPOLBPKMCYP19A1SMN1; SMN2 | |
| SCHEMBL22499593 | 1.00 | MAPT (0.57) | MAPTPOLBPKMCYP19A1SMN1; SMN2 | |
| SCHEMBL29381645 | 1.00 | MAPT (0.57) | MAPTPOLBPKMCYP19A1SMN1; SMN2 | |
| SCHEMBL22499562 | 0.95 | MAPT (0.63) | MAPTPOLBPKMCYP19A1SMN1; SMN2 | |
| SCHEMBL29382007 | 0.95 | MAPT (0.63) | MAPTPOLBPKMCYP19A1SMN1; SMN2 | |
| SCHEMBL22499511 | 0.86 | TBXA2R (0.53) | MAPTPOLBPKMCYP19A1SMN1; SMN2 | |
| SCHEMBL22499485 | 0.86 | TBXA2R (0.53) | MAPTPOLBPKMCYP19A1SMN1; SMN2 | |
| SCHEMBL29383984 | 0.86 | TBXA2R (0.53) | MAPTPOLBPKMCYP19A1SMN1; SMN2 | |
| SCHEMBL22499635 | 0.85 | ALDH1A1 (0.53) | MAPTPOLBPKMCYP19A1SMN1; SMN2 | |
| SCHEMBL22499540 | 0.85 | ALDH1A1 (0.53) | MAPTPOLBPKMCYP19A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3947345-A1 | MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION | Fondazione Istituto Italiano di Tecnologia (IT) | 2022-02-09 | — | — | EP | claimed |
| CN-114174259-A | Modulators of intracellular chloride concentration | 意大利学院科技基金会 | 2022-03-11 | — | — | CN | disclosed |
| EP-3947345-A1 | MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION | Fondazione Istituto Italiano di Tecnologia (IT) | 2022-02-09 | — | — | EP | disclosed |