Known targets — ChEMBL curated mechanism
ADRB1ADRB2SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Propafenone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.98 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.98 |
| ▸ | SCN5A known ✓ | Q14524 | 1/20 | 0.98 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 17/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.98 |
| ▸ | TSHR | P16473 | 2/20 | 0.98 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.98 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.98 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.98 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.98 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propafenone SCHEMBL41412 | 1.00 | MEN1 (1.00) | MEN1KMT2APMP22CYP3A4NPSR1 | |
| Propafenone SCHEMBL5529275 | 1.00 | MEN1 (1.00) | MEN1KMT2APMP22CYP3A4NPSR1 | |
| Propafenone SCHEMBL41413 | 0.99 | ABCB1 (1.00) | MEN1KMT2APMP22CYP3A4NPSR1 | |
| Propafenone SCHEMBL30416841 | 0.99 | ABCB1 (1.00) | MEN1KMT2APMP22CYP3A4NPSR1 | |
| Propafenone SCHEMBL27865 | 0.99 | ABCB1 (1.00) | MEN1KMT2APMP22CYP3A4NPSR1 | |
| Propafenone SCHEMBL16730120 | 0.99 | ABCB1 (1.00) | MEN1KMT2APMP22CYP3A4NPSR1 | |
| Propafenone SCHEMBL1651012 | 0.97 | ABCB1 (0.96) | MEN1KMT2APMP22CYP3A4NPSR1 | |
| SCHEMBL29419081 | 0.93 | ABCB1 (0.88) | MEN1KMT2APMP22CYP3A4NPSR1 | |
| Propafenone SCHEMBL15539494 | 0.90 | ABCB1 (0.83) | MEN1KMT2APMP22CYP3A4NPSR1 | |
| Propafenone SCHEMBL29393553 | 0.89 | MEN1 (0.80) | MEN1KMT2APMP22CYP3A4NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260109732-A1 | LIPID AMINES | MODERNATX INC (US) | 2026-04-23 | — | — | US | claimed |
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| CN-115267701-A | Interference detection shared signal generation method based on frequency shift convolution | 西安电子科技大学 | 2022-11-01 | — | — | CN | claimed |
| CN-114707767-A | Method for predicting peak-adjustable power of new energy power system in off-peak period | 长沙学院 | 2022-07-05 | — | — | CN | claimed |
| CN-114698012-A | Network vertical switching method of multi-mode intelligent terminal | 吉林大学 | 2022-07-01 | — | — | CN | claimed |
| CN-112279310-B | Preparation method of ternary cathode material precursor | 合肥国轩高科动力能源有限公司 | 2022-06-17 | — | — | CN | claimed |
| CN-111027593-B | Energy consumption abnormity detection method based on simulated annealing improved clonal selection algorithm | 广东工业大学 | 2022-06-14 | — | — | CN | claimed |
| CN-111734374-B | Associative polymer combination oil displacement method for greatly improving heterogeneous oil reservoir recovery ratio | 西南石油大学 | 2022-06-14 | — | — | CN | claimed |
| CN-112923623-B | Snow making machine with high snow making rate and control method and working method thereof | 西安交通大学 | 2022-06-07 | — | — | CN | claimed |
| CN-108961373-B | Hair rendering method and terminal | 福建天晴在线互动科技有限公司 | 2022-06-07 | — | — | CN | claimed |
| CN-111130694-B | PDCCH blind detection method and system for low-delay clustering | 重庆邮电大学 | 2022-05-03 | — | — | CN | claimed |
| CN-108038548-B | Quantum line realization method for image binarization | 杭州思源信息技术股份有限公司 | 2022-04-22 | — | — | CN | claimed |
| CN-216351386-U | Light emitting device and optical module | 青岛海信宽带多媒体技术有限公司 | 2022-04-19 | — | — | CN | claimed |
| CN-114330192-A | GaN HEMT transistor small signal model modeling method | 宁波大学 | 2022-04-12 | — | — | CN | claimed |
| CN-113128749-B | Centralized online planning method for satellite observation network | 中国科学院国家空间科学中心 | 2022-04-08 | — | — | CN | claimed |
| CN-111399018-B | Smoothing processing method and device for carrier phase in GNSS | 和芯星通科技(北京)有限公司 | 2022-04-01 | — | — | CN | claimed |
| CN-114046880-A | Color difference correction method for LED spliced display screen | 武汉华上科技有限公司 | 2022-02-15 | — | — | CN | claimed |
| US-20260109732-A1 | LIPID AMINES | MODERNATX INC (US) | 2026-04-23 | — | — | US | disclosed |
| CN-114046880-A | Color difference correction method for LED spliced display screen | 武汉华上科技有限公司 | 2022-02-15 | — | — | CN | disclosed |
| CN-114034296-A | Navigation signal interference source detection and identification method and system | 北京航空航天大学 | 2022-02-11 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260109732-A1 | LIPID AMINES | LDLR, NPC1, PHOSPHO1 | ADRB2 124/4885ADRB1 54/4885SCN5A 1712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.