Known targets — ChEMBL curated mechanism
ADRB1ADRB2SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Propafenone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.98 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.98 |
| ▸ | SCN5A known ✓ | Q14524 | 1/20 | 0.98 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 17/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.98 |
| ▸ | TSHR | P16473 | 2/20 | 0.98 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.98 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.98 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.98 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.98 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propafenone SCHEMBL29384899 | 1.00 | MEN1 (1.00) | MEN1KMT2APMP22CYP3A4NPSR1 | |
| Propafenone SCHEMBL41412 | 1.00 | MEN1 (1.00) | MEN1KMT2APMP22CYP3A4NPSR1 | |
| Propafenone SCHEMBL27865 | 0.99 | ABCB1 (1.00) | MEN1KMT2APMP22CYP3A4NPSR1 | |
| Propafenone SCHEMBL30416841 | 0.99 | ABCB1 (1.00) | MEN1KMT2APMP22CYP3A4NPSR1 | |
| Propafenone SCHEMBL41413 | 0.99 | ABCB1 (1.00) | MEN1KMT2APMP22CYP3A4NPSR1 | |
| Propafenone SCHEMBL16730120 | 0.99 | ABCB1 (1.00) | MEN1KMT2APMP22CYP3A4NPSR1 | |
| Propafenone SCHEMBL1651012 | 0.97 | ABCB1 (0.96) | MEN1KMT2APMP22CYP3A4NPSR1 | |
| SCHEMBL29419081 | 0.93 | ABCB1 (0.88) | MEN1KMT2APMP22CYP3A4NPSR1 | |
| Propafenone SCHEMBL15539494 | 0.90 | ABCB1 (0.83) | MEN1KMT2APMP22CYP3A4NPSR1 | |
| Propafenone SCHEMBL29393553 | 0.89 | MEN1 (0.80) | MEN1KMT2APMP22CYP3A4NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817427-A2 | METHOD FOR DETERMINING GENOTOXICITY | F. Hoffmann-Roche AG (CH) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006056340-A2 | METHOD FOR DETERMINING GENOTOXICITY | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-01 | — | — | WO | disclosed |