Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.36 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16668494 | 1.00 | SMN1; SMN2 (0.39) | SMN1; SMN2DYRK1ADYRK1BAURKACHEK1 | |
| SCHEMBL29385941 | 0.75 | SMN1; SMN2 (0.39) | SMN1; SMN2DYRK1ADYRK1BAURKACHEK1 | |
| SCHEMBL16668649 | 0.75 | SMN1; SMN2 (0.39) | SMN1; SMN2DYRK1ADYRK1BAURKACHEK1 | |
| SCHEMBL5489275 | 0.75 | FGFR1 (0.46) | SMN1; SMN2DYRK1ADYRK1BAURKACHEK1 | |
| SCHEMBL1500697 | 0.74 | SMN1; SMN2 (0.48) | SMN1; SMN2DYRK1ADYRK1BAURKACHEK1 | |
| SCHEMBL12687394 | 0.73 | DYRK1B (0.38) | SMN1; SMN2DYRK1ADYRK1BAURKACHEK1 | |
| SCHEMBL24674322 | 0.72 | DYRK1B (0.41) | SMN1; SMN2DYRK1ADYRK1BAURKACHEK1 | |
| SCHEMBL31390052 | 0.71 | SMN1; SMN2 (0.40) | SMN1; SMN2DYRK1ADYRK1BAURKACHEK1 | |
| SCHEMBL5492504 | 0.71 | SMN1; SMN2 (0.40) | SMN1; SMN2DYRK1ADYRK1BAURKACHEK1 | |
| SCHEMBL21853634 | 0.69 | HPGDS (0.42) | SMN1; SMN2DYRK1ADYRK1BAURKACHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110028491-B | Fibroblast growth factor receptor inhibitors | 缆图药品公司 | 2022-02-11 | — | — | CN | disclosed |