Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 13/20 | 0.77 |
| ▸ | MET | P08581 | 11/20 | 0.77 |
| ▸ | ALK | Q9UM73 | 10/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL886685 | 1.00 | INSR (0.77) | INSRMETALK | |
| SCHEMBL885837 | 0.90 | INSR (0.84) | INSRMETALK | |
| SCHEMBL886503 | 0.88 | INSR (0.82) | INSRMETALK | |
| SCHEMBL3264899 | 0.87 | INSR (0.58) | INSRMETALK | |
| SCHEMBL886140 | 0.87 | MET (1.00) | INSRMETALK | |
| SCHEMBL886604 | 0.84 | MET (0.83) | INSRMETALK | |
| SCHEMBL886097 | 0.83 | MET (0.84) | INSRMETALK | |
| SCHEMBL885948 | 0.83 | MET (1.00) | INSRMETALK | |
| SCHEMBL886059 | 0.82 | MET (0.89) | INSRMETALK | |
| SCHEMBL886643 | 0.82 | MET (1.00) | INSRMETALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |