Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.64 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.64 |
| ▸ | NT5E | P21589 | 3/20 | 0.62 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.48 |
| ▸ | SARS1 | P49591 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | MARS1 | P56192 | 1/20 | 0.46 |
| ▸ | ATG7 | O95352 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22498807 | 1.00 | PNP (0.64) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL766552 | 0.87 | ENPP1 (0.60) | ATG7ENPP1P2RY1 | |
| SCHEMBL16174396 | 0.87 | ENPP1 (0.60) | ATG7ENPP1P2RY1 | |
| SCHEMBL2788058 | 0.87 | ENPP1 (0.60) | ATG7ENPP1P2RY1 | |
| SCHEMBL6907647 | 0.84 | POLB (0.61) | PNPNT5EATG7 | |
| SCHEMBL29390167 | 0.83 | NT5E (0.67) | PDE4DPDE3ANT5ECA1CA2 | |
| SCHEMBL22498863 | 0.83 | NT5E (0.67) | PDE4DPDE3ANT5ECA1CA2 | |
| SCHEMBL12746240 | 0.83 | PNP (0.77) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL16366033 | 0.83 | PNP (0.77) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL16366051 | 0.81 | PNP (0.74) | PNPLMNATP53HTTPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3947408-A1 | SALT OF TRIPHOSPHATE PHOSPHORAMIDATES OF NUCLEOTIDES AS ANTICANCER COMPOUNDS | Nucana PLC (GB) | 2022-02-09 | — | — | EP | disclosed |