SCHEMBL2788058

SCHEMBL2788058

Cc1ccc(S(=O)(=O)OC[C@H]2O[C@@H](n3cnc4c(N)ncnc43)C[C@@H]2O)cc1

nearest known ligand 0.60

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ ENPP1 P22413 3/20 0.60
▸ P2RY1 P47900 1/20 0.60
▸ POLB P06746 1/20 0.59
▸ ATG7 O95352 10/20 0.55
▸ DTYMK P23919 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL766552 1.00 ENPP1 (0.60) ENPP1P2RY1POLBATG7DTYMK
SCHEMBL16174396 1.00 ENPP1 (0.60) ENPP1P2RY1POLBATG7DTYMK
SCHEMBL766139 0.90 ATG7 (0.56) ENPP1P2RY1POLBATG7
SCHEMBL29390156 0.87 PNP (0.64) ENPP1P2RY1ATG7
SCHEMBL22498807 0.87 PNP (0.64) ENPP1P2RY1ATG7
SCHEMBL4087758 0.85 RXFP1 (0.66) P2RY1
SCHEMBL3904204 0.85 RXFP1 (0.66) P2RY1
SCHEMBL13268677 0.84 POLB (0.58) ENPP1P2RY1POLBATG7DTYMK
SCHEMBL9856198 0.83 ADA (0.47) ENPP1P2RY1POLB
SCHEMBL6907647 0.83 POLB (0.61) POLBATG7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100291118-A1 Class of Gamma Delta T Cells Activators and Use Thereof INNATE PHARMA (FR) 2010-11-18 — — US disclosed
US-20100254940-A1 Compositions and Methods for Regulating an Immune Response in a Subject INNATE PHARMA, S.A. (FR) 2010-10-07 — — US disclosed
US-20100222306-A1 Class of Gamma Delta T Cells Activators and Use Thereof INNATE PHARMA, S.A. (FR) 2010-09-02 — — US disclosed
US-7767842-B2 Class of γδ T cells activators and use thereof INNATE PHARMA SA (FR) 2010-08-03 — — US disclosed
US-7683045-B2 Class of γδ T cells activators and use thereof INNATE PHARMA S.A. (FR) 2010-03-23 — — US disclosed
EP-1569656-B1 PHOSPHOANTIGENS FOR REGULATING AN IMMUNE RESPONSE INNATE PHARMA (FR) 2010-03-03 — — EP disclosed
EP-1761278-B1 ADJUVANT COMPOSITION AND METHODS FOR ITS USE INNATE PHARMA (FR) 2008-12-31 — — EP disclosed
US-20080207568-A1 Class of Gamma Delta T Cells Activators and Use Thereof INNATE PHARMA S.A. (FR) 2008-08-28 — — US disclosed
EP-1863572-A2 NEW CLASS OF T CELLS ACTIVATORS AND USE THEREOF Innate Pharma (FR) 2007-12-12 — — EP disclosed
US-20070249565-A1 Class of Gamma Delta T Cells Activators and Use Thereof INNATE PHARMA S.A. (FR) 2007-10-25 — — US disclosed
US-20070218086-A1 Adjuvant Composition and Methods for Its Use INNATE PHARMA, S.A. (FR) 2007-09-20 — — US disclosed
US-20070134273-A1 Composition and method for the treatment of carcinoma ROMAGNE FRANCOIS 2007-06-14 — — US disclosed
EP-1761278-A1 ADJUVANT COMPOSITION AND METHODS FOR ITS USE Innate Pharma (FR) 2007-03-14 — — EP disclosed
EP-1720567-A2 COMPOSITION AND METHOD FOR THE TREATMENT OF CARCINOMA Innate Pharma (FR) 2006-11-15 — — EP disclosed
WO-2006103568-A2 NEW CLASS OF Ϝδ T CELLS ACTIVATORS AND USE THEREOF INNATE PHARMA (FR) 2006-10-05 — — WO disclosed
US-20060194755-A1 Compositions and methods for regulating an immune response in a subject INNATE PHARMA, S.A.S. (FR) 2006-08-31 — — US disclosed
EP-1689758-A2 NEW CLASS OF GAMMA DELTA T CELLS ACTIVATORS AND USE THEREOF Innate Pharma (FR) 2006-08-16 — — EP disclosed
WO-2005102385-A1 ADJUVANT COMPOSITION AND METHODS FOR ITS USE INNATE PHARMA (FR) 2005-11-03 — — WO disclosed
WO-2005077411-A2 COMPOSITION AND METHOD FOR THE TREATMENT OF CARCINOMA INNATE PHARMA (FR) 2005-08-25 — — WO disclosed
WO-2005054258-A2 NEW CLASS OF GAMMA DELTA T CELLS ACTIVATORS AND USE THEREOF INNATE PHARMA (FR) 2005-06-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100254940-A1 Compositions and Methods for Regulating an Immune Response in a Subject IFNG, IL2, ICOS ENPP1 1076/4885P2RY1 586/4885POLB 2836/4885
US-20080207568-A1 Class of Gamma Delta T Cells Activators and Use Thereof NFATC1, CD4, CD74 ENPP1 1470/4885P2RY1 522/4885POLB 2623/4885
US-20070218086-A1 Adjuvant Composition and Methods for Its Use CD4, CD69, ICOS ENPP1 2055/4885P2RY1 1917/4885POLB 644/4885
US-20070134273-A1 Composition and method for the treatment of carcinoma IFNG, IL2, PBK ENPP1 1323/4885P2RY1 2629/4885POLB 601/4885
US-20100291118-A1 Class of Gamma Delta T Cells Activators and Use Thereof CD4, IFNG, NFATC1 ENPP1 1909/4885P2RY1 900/4885POLB 609/4885
US-20060194755-A1 Compositions and methods for regulating an immune response in a subject IFNG, IL2, ICOS ENPP1 1078/4885P2RY1 588/4885POLB 2656/4885
US-20100222306-A1 Class of Gamma Delta T Cells Activators and Use Thereof NFATC1, CD4, CD74 ENPP1 1470/4885P2RY1 522/4885POLB 2623/4885
US-20070249565-A1 Class of Gamma Delta T Cells Activators and Use Thereof CD4, IFNG, NFATC1 ENPP1 1909/4885P2RY1 900/4885POLB 609/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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