Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIOK3 | O14730 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 12/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | WEE2 | P0C1S8 | 2/20 | 0.43 |
| ▸ | WEE1 | P30291 | 2/20 | 0.43 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.43 |
| ▸ | FYN | P06241 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | STK25 | O00506 | 1/20 | 0.42 |
| ▸ | CIT | O14578 | 1/20 | 0.42 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | CASK | O14936 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.42 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.42 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3194260 | 0.72 | SRC (0.73) | RIOK3SRCWEE2WEE1PKMYT1 | |
| SCHEMBL4489514 | 0.68 | WEE2 (0.71) | RIOK3SRCKDRWEE2WEE1 | |
| SCHEMBL4764821 | 0.68 | SRC (0.51) | RIOK3SRCKDRWEE2WEE1 | |
| SCHEMBL16827594 | 0.67 | HRH3 (0.54) | SRCFYNDRD3HRH3CHEK1 | |
| SCHEMBL16618011 | 0.66 | LMNA (0.45) | RIOK3SRCKDRWEE2WEE1 | |
| SCHEMBL30544811 | 0.66 | SRC (0.57) | RIOK3SRCKDRWEE2WEE1 | |
| SCHEMBL30326588 | 0.65 | HRH3 (0.57) | DRD3HRH3CHEK1HRH2SLC6A4 | |
| SCHEMBL12311793 | 0.65 | HRH3 (0.60) | DRD3HRH3DRD2SLC6A2HTR2A | |
| SCHEMBL16747775 | 0.65 | BRD4 (0.48) | SRCKDRDRD3DRD2TERT | |
| SCHEMBL2206979 | 0.65 | HRH3 (0.59) | DRD3HRH3DRD2SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902029-B2 | CRYSTALLINE FORMS OF 4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYL-1-PIPERAZINYL)PROPOXY]-3-QUINOLINECARB-ONITRILE AND METHODS OF PREPARING THE SAME | WYETH LLC (US) | 2022-02-16 | — | — | EP | disclosed |