Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 5/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 3/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | GPR174 | Q9BXC1 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18662613 | 1.00 | PIN1 (0.39) | PIN1HSD11B1L3MBTL1HTR6HTR2A | |
| SCHEMBL18662695 | 0.91 | PIN1 (0.39) | PIN1HSD11B1L3MBTL1HTR6HTR2A | |
| SCHEMBL29394664 | 0.91 | PIN1 (0.39) | PIN1HSD11B1L3MBTL1HTR6HTR2A | |
| SCHEMBL18662641 | 0.91 | HSD11B1 (0.40) | PIN1HSD11B1L3MBTL1HTR6HTR2A | |
| SCHEMBL29394672 | 0.91 | HSD11B1 (0.40) | PIN1HSD11B1L3MBTL1HTR6HTR2A | |
| SCHEMBL29395224 | 0.89 | ABL1 (0.43) | PIN1HSD11B1L3MBTL1HTR6HTR2A | |
| SCHEMBL18662673 | 0.89 | ABL1 (0.43) | PIN1HSD11B1L3MBTL1HTR6HTR2A | |
| SCHEMBL30018893 | 0.83 | PIN1 (0.39) | PIN1L3MBTL1HTR6ALDH1A1MAPT | |
| SCHEMBL20399914 | 0.83 | PIN1 (0.39) | PIN1L3MBTL1HTR6ALDH1A1MAPT | |
| SCHEMBL18662689 | 0.82 | HSD11B1 (0.40) | PIN1HSD11B1L3MBTL1HTR6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12319670-B2 | Compounds and methods for inhibiting JAK | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2025-06-03 | — | — | US | disclosed |
| CN-115925693-B | JAK1 selective inhibitors | 阿斯利康(瑞典)有限公司 | 2024-11-12 | — | — | CN | disclosed |
| CN-118580223-A | Xinafoate salts of JAK inhibiting compounds | 阿斯利康(瑞典)有限公司 | 2024-09-03 | — | — | CN | disclosed |
| CN-112424187-B | Xinafoate salts of JAK inhibiting compounds | 阿斯利康(瑞典)有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-113710664-B | JAK1 selective kinase inhibitors | 迪哲(江苏)医药股份有限公司 | 2024-01-26 | — | — | CN | disclosed |
| CN-115925693-A | Selective inhibitors of JAK1 | 阿斯利康(瑞典)有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-110461830-B | Selective inhibitors of JAK1 | 阿斯利康(瑞典)有限公司 | 2022-11-01 | — | — | CN | disclosed |
| US-20220119372-A1 | COMPOUNDS AND METHODS FOR INHIBITING JAK | DIZAL JIANGSU PHARMACEUTICAL CO LTD (CN) | 2022-04-21 | — | — | US | disclosed |
| US-11247983-B2 | Compounds and methods for inhibiting JAK | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2022-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12319670-B2 | Compounds and methods for inhibiting JAK | JAK2, JAK3, JAK1 | PIN1 4383/4885HSD11B1 1204/4885L3MBTL1 465/4885 |
| US-20220119372-A1 | COMPOUNDS AND METHODS FOR INHIBITING JAK | JAK2, JAK3, JAK1 | PIN1 4383/4885HSD11B1 1204/4885L3MBTL1 465/4885 |
| US-11247983-B2 | Compounds and methods for inhibiting JAK | JAK2, JAK3, JAK1 | PIN1 4383/4885HSD11B1 1204/4885L3MBTL1 465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.