Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fasudil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 known ✓ | O75116 | 8/20 | 1.00 |
| ▸ | ROCK1 known ✓ | Q13464 | 7/20 | 1.00 |
| ▸ | CCR2 | P41597 | 2/20 | 1.00 |
| ▸ | HTT | P42858 | 2/20 | 1.00 |
| ▸ | PRKCE | Q02156 | 6/20 | 0.98 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.98 |
| ▸ | PRKD1 | Q15139 | 6/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.98 |
| ▸ | PRKD3 | O94806 | 5/20 | 0.98 |
| ▸ | PRKCG | P05129 | 5/20 | 0.98 |
| ▸ | PRKCB | P05771 | 5/20 | 0.98 |
| ▸ | PRKCA | P17252 | 5/20 | 0.98 |
| ▸ | PRKCH | P24723 | 5/20 | 0.98 |
| ▸ | PRKCI | P41743 | 5/20 | 0.98 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.98 |
| ▸ | PRKCZ | Q05513 | 5/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.98 |
| ▸ | PRKACA | P17612 | 4/20 | 0.98 |
| ▸ | PRKACG | P22612 | 4/20 | 0.98 |
| ▸ | PRKACB | P22694 | 4/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fasudil SCHEMBL29351490 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1CCR2HTTPRKCE | |
| Fasudil SCHEMBL599053 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1CCR2HTTPRKCE | |
| Fasudil SCHEMBL30084458 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1CCR2HTTPRKCE | |
| Fasudil SCHEMBL317082 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1CCR2HTTPRKCE | |
| Fasudil SCHEMBL6032335 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1CCR2HTTPRKCE | |
| Fasudil SCHEMBL30064396 | 0.99 | ROCK2 (0.98) | ROCK2ROCK1CCR2HTTPRKCE | |
| Fasudil SCHEMBL6269513 | 0.99 | ROCK2 (0.98) | ROCK2ROCK1CCR2HTTPRKCE | |
| Fasudil SCHEMBL4728659 | 0.99 | ROCK2 (0.98) | ROCK2ROCK1CCR2HTTPRKCE | |
| Fasudil SCHEMBL4725334 | 0.99 | ROCK2 (0.98) | ROCK2ROCK1CCR2HTTPRKCE | |
| Fasudil SCHEMBL2154690 | 0.99 | ROCK2 (0.98) | ROCK2ROCK1CCR2HTTPRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12258583-B2 | Embryonic erythroblast-containing cell population and method for producing same, cell culture composition, and compound test method | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2025-03-25 | — | — | US | disclosed |
| EP-4498942-A1 | SYSTEMS AND METHODS FOR THE TREATMENT OF CANCER USING ULTRASOUND | Duke University (US) | 2025-02-05 | — | — | EP | disclosed |
| CN-115925713-B | Diazamacrocyclic compound intermediate, and preparation method and application thereof | 苏州百灵威超精细材料有限公司 | 2024-12-24 | — | — | CN | disclosed |
| CN-119136746-A | System and method for treating cancer using ultrasound | 杜克大学 | 2024-12-13 | — | — | CN | disclosed |
| US-20240400983-A1 | CELL AGGREGATE INCLUDING PITUITARY HORMONE-PRODUCING CELLS AND METHOD FOR PRODUCING SAME | Sumitomo Pharma Co., Ltd. (JP) | 2024-12-05 | — | — | US | disclosed |
| US-20240392241-A1 | METHOD FOR PRODUCING CELL MASS INCLUDING PITUITARY TISSUE AND CELL MASS | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2024-11-28 | — | — | US | disclosed |
| CN-112840016-B | Cell culture substrate, method for producing cell culture substrate, and method for producing spheroid | 东曹株式会社 | 2024-10-25 | — | — | CN | disclosed |
| CN-113207297-B | Cell population comprising embryonic erythroblasts, method for preparing same, cell culture composition and method for testing compounds | 住友化学株式会社 | 2024-09-24 | — | — | CN | disclosed |
| WO-2024171957-A1 | TRANSPLANTATION OF PITUITARY HORMONE-PRODUCING CELLS | 国立大学法人東海国立大学機構 | 2024-08-22 | — | — | WO | disclosed |
| EP-4410963-A1 | METHOD FOR PRODUCING CELL MASS INCLUDING PITUITARY TISSUE AND CELL MASS | Sumitomo Chemical Company, Limited (JP) | 2024-08-07 | — | — | EP | disclosed |
| WO-2023192329-A1 | SYSTEMS AND METHODS FOR THE TREATMENT OF CANCER USING ULTRASOUND | DUKE UNIVERSITY (US) | 2023-10-05 | — | — | WO | disclosed |
| CN-109312301-B | Method for preparing cultured epithelial cell sheet | 京都府公立大学法人 | 2023-06-16 | — | — | CN | disclosed |
| CN-115925713-A | Diazacyclocycle compound intermediate and preparation method and application thereof | 苏州百灵威超精细材料有限公司 | 2023-04-07 | — | — | CN | disclosed |
| WO-2023054395-A1 | CELL AGGREGATE INCLUDING PITUITARY HORMONE-PRODUCING CELLS AND METHOD FOR PRODUCING SAME | 住友ファーマ株式会社 | 2023-04-06 | — | — | WO | disclosed |
| WO-2023054396-A1 | METHOD FOR PRODUCING CELL MASS INCLUDING PITUITARY TISSUE AND CELL MASS | 住友化学株式会社 | 2023-04-06 | — | — | WO | disclosed |
| WO-2023277135-A1 | METHOD FOR PRODUCING CELLS CONSTITUTING NASAL EPITHELIUM, AND CELL POPULATION INCLUDING CELLS CONSTITUTING NASAL EPITHELIUM OR PROGENITOR CELLS THEREOF | 住友化学株式会社 | 2023-01-05 | — | — | WO | disclosed |
| CN-110220989-B | Method for detecting fasudil hydrochloride and 9 related substances thereof | 陈海鹏 | 2022-04-22 | — | — | CN | disclosed |
| CN-108350427-B | ROR1 positive mesenchymal stem cells and pharmaceutical composition comprising same | 日本乐敦制药株式会社 | 2022-03-11 | — | — | CN | disclosed |
| EP-3199162-B1 | PHARMACEUTICAL PRODUCT | KOWA CO (JP) | 2022-03-09 | — | — | EP | disclosed |
| US-20220049220-A1 | EMBRYONIC ERYTHROBLAST-CONTAINING CELL POPULATION AND METHOD FOR PRODUCING SAME, CELL CULTURE COMPOSITION, AND COMPOUND TEST METHOD | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2022-02-17 | — | — | US | disclosed |