Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fasudil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 known ✓ | O75116 | 8/20 | 0.98 |
| ▸ | ROCK1 known ✓ | Q13464 | 7/20 | 0.98 |
| ▸ | CCR2 | P41597 | 2/20 | 0.98 |
| ▸ | HTT | P42858 | 2/20 | 0.98 |
| ▸ | PRKCE | Q02156 | 6/20 | 0.95 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.95 |
| ▸ | PRKD1 | Q15139 | 6/20 | 0.95 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.95 |
| ▸ | PRKD3 | O94806 | 5/20 | 0.95 |
| ▸ | PRKCG | P05129 | 5/20 | 0.95 |
| ▸ | PRKCB | P05771 | 5/20 | 0.95 |
| ▸ | PRKCA | P17252 | 5/20 | 0.95 |
| ▸ | PRKCH | P24723 | 5/20 | 0.95 |
| ▸ | PRKCI | P41743 | 5/20 | 0.95 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.95 |
| ▸ | PRKCZ | Q05513 | 5/20 | 0.95 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.95 |
| ▸ | PRKACA | P17612 | 4/20 | 0.95 |
| ▸ | PRKACG | P22612 | 4/20 | 0.95 |
| ▸ | PRKACB | P22694 | 4/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fasudil SCHEMBL2154690 | 1.00 | ROCK2 (0.98) | ROCK2ROCK1CCR2HTTPRKCE | |
| Fasudil SCHEMBL30064396 | 1.00 | ROCK2 (0.98) | ROCK2ROCK1CCR2HTTPRKCE | |
| Fasudil SCHEMBL4725334 | 1.00 | ROCK2 (0.98) | ROCK2ROCK1CCR2HTTPRKCE | |
| Fasudil SCHEMBL4728659 | 1.00 | ROCK2 (0.98) | ROCK2ROCK1CCR2HTTPRKCE | |
| Fasudil SCHEMBL30084458 | 0.99 | ROCK2 (1.00) | ROCK2ROCK1CCR2HTTPRKCE | |
| Fasudil SCHEMBL6032335 | 0.99 | ROCK2 (1.00) | ROCK2ROCK1CCR2HTTPRKCE | |
| Fasudil SCHEMBL29351490 | 0.99 | ROCK2 (1.00) | ROCK2ROCK1CCR2HTTPRKCE | |
| Fasudil SCHEMBL29393852 | 0.99 | ROCK2 (1.00) | ROCK2ROCK1CCR2HTTPRKCE | |
| Fasudil SCHEMBL599053 | 0.99 | ROCK2 (1.00) | ROCK2ROCK1CCR2HTTPRKCE | |
| Fasudil SCHEMBL317082 | 0.99 | ROCK2 (1.00) | ROCK2ROCK1CCR2HTTPRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005117896-A1 | FORMULATIONS CONTAINING FASUDIL, A MATRIX AND AN ENVELOPE | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-12-15 | — | — | WO | claimed |
| WO-2005117896-A1 | FORMULATIONS CONTAINING FASUDIL, A MATRIX AND AN ENVELOPE | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-12-15 | — | — | WO | disclosed |