Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.56 |
| ▸ | HTR3B | O95264 | 1/20 | 0.56 |
| ▸ | HTR3A | P46098 | 1/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | NPFFR2 | Q9Y5X5 | 3/20 | 0.39 |
| ▸ | NPFFR1 | Q9GZQ6 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL58303 | 1.00 | MAPK1 (0.61) | MAPK1TDP1HTR3EHTR3BHTR3A | |
| Tetrahydrofuran SCHEMBL28279164 | 0.88 | MAPK1 (0.49) | MAPK1TDP1HTR3EHTR3BHTR3A | |
| SCHEMBL8593598 | 0.87 | MAPK1 (0.47) | MAPK1TDP1HTR3EHTR3BHTR3A | |
| SCHEMBL856525 | 0.86 | MAPK1 (0.61) | MAPK1TDP1HTR3EHTR3BHTR3A | |
| SCHEMBL10788009 | 0.84 | MAPK1 (0.63) | MAPK1TDP1HTR3EHTR3BHTR3A | |
| SCHEMBL1555041 | 0.83 | MAPK1 (0.47) | MAPK1TDP1HTR3EHTR3BHTR3A | |
| SCHEMBL881834 | 0.82 | HTR3E (0.56) | MAPK1TDP1HTR3EHTR3BHTR3A | |
| SCHEMBL3837474 | 0.82 | MAPK1 (0.42) | MAPK1TDP1HTR3EHTR3BHTR3A | |
| SCHEMBL7177146 | 0.81 | MAPK1 (0.46) | MAPK1TDP1HTR3EHTR3BHTR3A | |
| SCHEMBL29648906 | 0.80 | MAPK1 (0.44) | MAPK1TDP1HTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115108977-B | Regorafenib preparation method of nylon | 南京正大天晴制药有限公司 | 2024-11-29 | — | — | CN | disclosed |
| CN-111892533-B | Regorafenib related substance, and preparation method and application thereof | 石药集团中奇制药技术（石家庄）有限公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-114315710-B | Method for preparing or purifying regorafenib | 江苏豪森药业集团有限公司 | 2024-04-26 | — | — | CN | disclosed |
| CN-114920689-B | Preparation method of regorafenib intermediate | 石药集团中奇制药技术（石家庄）有限公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-109796401-B | Preparation method of regorafenib bulk drug | 新乡双鹭药业有限公司 | 2023-10-17 | — | — | CN | disclosed |
| CN-109796401-B | Preparation method of regorafenib bulk drug | 新乡双鹭药业有限公司 | 2023-10-17 | — | — | CN | disclosed |
| CN-116710453-A | Kinase inhibitors and uses thereof | 璧辰医药技术股份有限公司 | 2023-09-05 | — | — | CN | disclosed |
| EP-4192582-A1 | KINASE INHIBITORS AND USES THEREOF | ABM Therapeutics Corporation (US) | 2023-06-14 | — | — | EP | disclosed |
| CN-112020525-B | Adducts of amine catalysts for preparing isocyanurate polymers | 科思创知识产权两合公司 | 2023-05-16 | — | — | CN | disclosed |
| CN-115991673-A | Purification method of regorafenib | 四川科伦药物研究院有限公司 | 2023-04-21 | — | — | CN | disclosed |
| CN-115108977-A | Preparation method of regorafenib | 南京正大天晴制药有限公司 | 2022-09-27 | — | — | CN | disclosed |
| CN-114920689-A | Preparation method of regorafenib intermediate | 石药集团中奇制药技术（石家庄）有限公司 | 2022-08-19 | — | — | CN | disclosed |
| CN-108794411-B | Certain chemical entities, compositions, and methods | 润新生物公司 | 2022-06-07 | — | — | CN | disclosed |
| CN-110068616-B | Normal phase chromatographic analysis method for 4-chlorine-2 nitrophenyl isocyanate and reaction liquid thereof | 联化科技股份有限公司 | 2022-06-03 | — | — | CN | disclosed |
| EP-3999057-A1 | POLYAROMATIC UREA DERIVATIVES AND THEIR USE IN THE TREATMENT OF MUSCLE DISEASES | ANAGENESIS BIOTECHNOLOGIES SAS (FR) | 2022-05-25 | — | — | EP | disclosed |
| EP-3997149-A1 | POLYMERIZABLE COMPOSITIONS FOR PREPARING POLYISOCYANURATE-BASED PLASTICS HAVING EXTENDED WORKLIFE | Covestro Intellectual Property GmbH & Co. KG (DE) | 2022-05-18 | — | — | EP | disclosed |
| CN-110885298-B | Synthesis method of 4-chloro-3- (trifluoromethyl) phenylisocyanate | 山东金城医药化工有限公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-114315710-A | Method for preparing or purifying regorafenib | 江苏豪森药业集团有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-114144410-A | Polyarylurea derivatives and their use in the treatment of muscular diseases | 阿纳格纳斯生物技术股份有限公司 | 2022-03-04 | — | — | CN | disclosed |
| WO-2022032071-A1 | KINASE INHIBITORS AND USES THEREOF | ABM THERAPEUTICS CORPORATION (US) | 2022-02-10 | — | — | WO | disclosed |