Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 17/20 | 0.60 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3729235 | 0.92 | IGF1R (0.59) | IGF1R | |
| SCHEMBL2939681 | 0.86 | IGF1R (0.48) | IGF1RTAS2R8HTR1AHTR7HTR6 | |
| SCHEMBL2940459 | 0.84 | IGF1R (0.64) | IGF1RTAS2R8 | |
| Trifluoroacetic Acid SCHEMBL3728009 | 0.80 | IGF1R (0.49) | IGF1R | |
| SCHEMBL2937078 | 0.79 | IGF1R (0.75) | IGF1RTAS2R8 | |
| Trifluoroacetic Acid SCHEMBL3734614 | 0.77 | IGF1R (0.63) | IGF1R | |
| SCHEMBL2937352 | 0.76 | IGF1R (0.71) | IGF1RTAS2R8 | |
| SCHEMBL1130587 | 0.75 | IGF1R (1.00) | IGF1R | |
| SCHEMBL4888208 | 0.75 | IGF1R (0.72) | IGF1RTAS2R8 | |
| SCHEMBL4881494 | 0.75 | IGF1R (0.62) | IGF1RTAS2R8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-B1 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2010-09-22 | — | — | EP | disclosed |
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |