SCHEMBL2940459

SCHEMBL2940459

COCCCSc1ccc(N2C(=O)N(Cc3ccncc3)C(C)(C)C2=O)cc1

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IGF1R P08069 18/20 0.64
TAS2R8 Q9NYW2 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL3734614 0.92 IGF1R (0.63) IGF1R
SCHEMBL2941557 0.86 IGF1R (0.51) IGF1RTAS2R8
SCHEMBL2940028 0.84 IGF1R (0.60) IGF1RTAS2R8
SCHEMBL2937078 0.82 IGF1R (0.75) IGF1RTAS2R8
Trifluoroacetic Acid SCHEMBL3730716 0.80 IGF1R (0.51) IGF1R
SCHEMBL2937352 0.79 IGF1R (0.71) IGF1RTAS2R8
SCHEMBL1130587 0.78 IGF1R (1.00) IGF1R
SCHEMBL4888208 0.78 IGF1R (0.72) IGF1RTAS2R8
Trifluoroacetic Acid SCHEMBL3729235 0.78 IGF1R (0.59) IGF1R
SCHEMBL13039129 0.77 IGF1R (0.67) IGF1RTAS2R8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-B1 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA SA (FR) 2010-09-22 EP disclosed