Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 3/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.40 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.40 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29870434 | 1.00 | NAAA (0.43) | NAAATP53HPGDALOX12CNR1 | |
| SCHEMBL10704937 | 1.00 | NAAA (0.43) | NAAATP53HPGDALOX12CNR1 | |
| SCHEMBL29400724 | 0.99 | NAAA (0.41) | NAAATP53HPGDALOX12CNR1 | |
| SCHEMBL29397580 | 0.94 | USP2 (0.38) | NAAATP53HPGDALOX12MEN1 | |
| SCHEMBL30985368 | 0.89 | TP53 (0.43) | TP53HPGDALOX12CNR1CNR2 | |
| SCHEMBL30985315 | 0.89 | TP53 (0.43) | TP53HPGDALOX12CNR1CNR2 | |
| SCHEMBL30985338 | 0.89 | TP53 (0.43) | TP53HPGDALOX12CNR1CNR2 | |
| SCHEMBL16569372 | 0.88 | ALDH1A1 (0.39) | HPGDMEN1KMT2A | |
| SCHEMBL20764812 | 0.88 | ALDH1A1 (0.39) | HPGDMEN1KMT2A | |
| SCHEMBL13771143 | 0.87 | TP53 (0.42) | TP53HPGDALOX12MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112920167-B | Double-target inhibitor targeting FGFR and HDAC, preparation method and application thereof, pharmaceutical composition and medicament | 四川大学华西医院 | 2022-08-26 | — | — | CN | disclosed |
| WO-2022037365-A1 | DOUBLE-TARGET INHIBITOR TARGETING FGFR AND HDAC, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF, PHARMACEUTICAL COMPOSITION AND MEDICAMENT | 四川大学华西医院 | 2022-02-24 | — | — | WO | disclosed |