Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 1.00 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 1.00 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 1.00 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.64 |
| ▸ | RELA | Q04206 | 1/20 | 0.64 |
| ▸ | NQO1 | P15559 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL970943 | 1.00 | MAPT (1.00) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8651660 | 0.88 | MAPT (0.78) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL31238099 | 0.88 | MEN1 (0.78) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL13940470 | 0.87 | MAPT (0.77) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8656092 | 0.87 | MAPT (0.77) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL10506584 | 0.84 | MAPT (0.71) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL10506975 | 0.84 | ALDH1A1 (0.71) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL10504983 | 0.84 | MAPT (0.71) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8368653 | 0.83 | MAPT (0.70) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8656023 | 0.81 | MAPT (0.68) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3956021-A1 | METHODS OF TREATING HYPERTENSION WITH ACTIVATORS OF TIE-2 | EyePoint Pharmaceuticals, Inc. (US) | 2022-02-23 | — | — | EP | disclosed |
| CN-114072205-A | Method of treating hypertension with TIE-2 activator | 视点制药公司 | 2022-02-18 | — | — | CN | disclosed |