Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | MEN1 | O00255 | 5/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.70 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.70 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.70 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.70 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.70 |
| ▸ | BLM | P54132 | 5/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | CASP3 | P42574 | 4/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 4/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 4/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8371672 | 0.84 | CDK4 (0.58) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8367302 | 0.84 | CDK4 (0.56) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL970943 | 0.83 | MAPT (1.00) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL29401747 | 0.83 | MAPT (1.00) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8651660 | 0.83 | MAPT (0.78) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL10778656 | 0.82 | KMT2A (0.50) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8368911 | 0.82 | MAPT (0.50) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8368850 | 0.82 | SMN1; SMN2 (0.50) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8368885 | 0.80 | MEN1 (0.48) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8369508 | 0.80 | CDK4 (0.60) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0107365-B1 | 6-ANILINO-5,8-QUINOXALINEDIONES | ELI LILLY AND COMPANY (US) | 1987-07-22 | — | — | EP | claimed |
| EP-0107365-A2 | 6-Anilino-5,8-quinoxalinediones | ELI LILLY AND COMPANY (US) | 1984-05-02 | — | — | EP | claimed |
| WO-1999052365-A1 | ANTICANCER AGENTS | ELI LILLY AND COMPANY (US) | 1999-10-21 | — | — | WO | disclosed |
| EP-0107365-B1 | 6-ANILINO-5,8-QUINOXALINEDIONES | ELI LILLY AND COMPANY (US) | 1987-07-22 | — | — | EP | disclosed |
| EP-0107365-B1 | 6-ANILINO-5,8-QUINOXALINEDIONES | ELI LILLY AND COMPANY (US) | 1987-07-22 | — | — | EP | disclosed |
| US-4486432-A | ANTIASTHMA | ELI LILLY AND COMPANY (US) | 1984-12-04 | — | — | US | disclosed |
| EP-0107365-A2 | 6-Anilino-5,8-quinoxalinediones | ELI LILLY AND COMPANY (US) | 1984-05-02 | — | — | EP | disclosed |
| EP-0107365-A2 | 6-Anilino-5,8-quinoxalinediones | ELI LILLY AND COMPANY (US) | 1984-05-02 | — | — | EP | disclosed |
| EP-0107365-A2 | 6-Anilino-5,8-quinoxalinediones | ELI LILLY AND COMPANY (US) | 1984-05-02 | — | — | EP | disclosed |