Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 3/20 | 0.49 |
| ▸ | GRM5 | P41594 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22659299 | 1.00 | NTRK1 (0.49) | NTRK1GRM5MAPTRAB9ATRPV1 | |
| SCHEMBL22659187 | 0.85 | KCNT1 (0.40) | NTRK1STIM1ORAI1 | |
| SCHEMBL24571464 | 0.83 | MAPT (0.50) | NTRK1GRM5MAPTRAB9ATRPV1 | |
| SCHEMBL29403364 | 0.83 | MAPT (0.50) | NTRK1GRM5MAPTRAB9ATRPV1 | |
| SCHEMBL22659356 | 0.80 | NTRK1 (0.51) | NTRK1GRM5MAPTRAB9A | |
| SCHEMBL24571207 | 0.80 | ABL1 (0.42) | NTRK1GRM5MAPT | |
| SCHEMBL22659199 | 0.78 | BRAF (0.46) | NTRK1MAPTRAB9ATRPV1 | |
| SCHEMBL24571432 | 0.78 | NTRK1 (0.42) | NTRK1MAPTRAB9ASTIM1ORAI1 | |
| SCHEMBL29403296 | 0.78 | BRAF (0.46) | NTRK1MAPTRAB9ATRPV1 | |
| SCHEMBL22659881 | 0.76 | ABL1 (0.46) | NTRK1GRM5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3966208-A2 | COMPOUNDS AND METHODS FOR TREATING CANCER | Antidote IP Holdings, LLC (US) | 2022-03-16 | — | — | EP | disclosed |