Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.51 |
| ▸ | AOC3 | Q16853 | 11/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.46 |
| ▸ | EP300 | Q09472 | 1/20 | 0.46 |
| ▸ | CCNC | P24863 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22919226 | 1.00 | CASP6 (0.51) | CASP6GFERENPP2AOC3MEN1 | |
| SCHEMBL2894290 | 0.87 | AOC3 (0.45) | ENPP2AOC3MAPTEP300 | |
| SCHEMBL22914764 | 0.84 | CYP2C9 (0.57) | MEN1KMT2A | |
| SCHEMBL2118022 | 0.82 | PANK3 (0.46) | ENPP2AOC3MAPT | |
| SCHEMBL1432924 | 0.82 | GPR119 (0.57) | MEN1MAPTKMT2AEGLN2 | |
| SCHEMBL30893576 | 0.82 | GPR119 (0.57) | MEN1MAPTKMT2AEGLN2 | |
| SCHEMBL29612110 | 0.80 | CHEK1 (0.51) | GFERAOC3MEN1MAPTKMT2A | |
| SCHEMBL151032 | 0.80 | CHEK1 (0.51) | GFERAOC3MEN1MAPTKMT2A | |
| SCHEMBL13616130 | 0.79 | CASP6 (0.57) | CASP6GFERAOC3MEN1MAPT | |
| SCHEMBL151047 | 0.78 | MAPT (0.46) | AOC3MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118666853-A | N-methyl N- (6- (methoxy) pyridazin-3-yl) amine derivatives for the treatment of inflammatory airway diseases or fibrotic diseases | 勃林格殷格翰国际有限公司 | 2024-09-20 | — | — | CN | disclosed |
| CN-114206876-B | N-methyl, N- (6- (methoxy) pyridazin-3-yl) amine derivatives as modulators of Autotaxin (ATX) for the treatment of inflammatory airway diseases or fibrotic diseases | 勃林格殷格翰国际有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-114206876-A | N-methyl, N- (6- (methoxy) pyridazin-3-yl) amine derivatives as Autotaxin (ATX) modulators for the treatment of inflammatory airway diseases or fibrotic diseases | 勃林格殷格翰国际有限公司 | 2022-03-18 | — | — | CN | disclosed |