Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | F11 | P03951 | 9/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 7/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22993238 | 0.91 | HDAC1 (0.46) | HDAC1F11ESR2KLKB1NR1H2 | |
| SCHEMBL29388404 | 0.84 | NR1H2 (0.49) | HDAC1F11ESR2KLKB1NR1H2 | |
| SCHEMBL22993173 | 0.84 | NR1H2 (0.49) | HDAC1F11ESR2KLKB1NR1H2 | |
| SCHEMBL22981213 | 0.80 | F11 (0.45) | F11KLKB1 | |
| SCHEMBL18379719 | 0.80 | ESR2 (0.55) | HDAC1ESR2NR1H2DDB1CRBN | |
| SCHEMBL26227498 | 0.79 | F11 (0.44) | F11KLKB1 | |
| Lithium SCHEMBL29407575 | 0.79 | F11 (0.54) | F11KLKB1 | |
| SCHEMBL22982177 | 0.76 | F11 (0.51) | F11KLKB1 | |
| SCHEMBL22981314 | 0.75 | F11 (0.47) | F11KLKB1 | |
| SCHEMBL29407328 | 0.74 | HDAC1 (0.46) | HDAC1ESR2NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010333-A1 | PLASMA KALLIKREIN INHIBITORS | Kalvista Pharmaceuticals Limited (GB) | 2022-06-15 | — | — | EP | disclosed |
| CN-114206852-A | Plasma kallikrein inhibitors | 卡尔维斯塔制药有限公司 | 2022-03-18 | — | — | CN | disclosed |