Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.34 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22659128 | 1.00 | DYRK1A (0.39) | DYRK1ALRRK2PRMT5METTL3WDR77 | |
| SCHEMBL22659126 | 1.00 | DYRK1A (0.39) | DYRK1ALRRK2PRMT5METTL3WDR77 | |
| SCHEMBL22675823 | 0.77 | METTL3 (0.38) | METTL3CYP3A4CYP2D6FGFR1CYP2C9 | |
| SCHEMBL29407676 | 0.77 | METTL3 (0.38) | METTL3CYP3A4CYP2D6FGFR1CYP2C9 | |
| SCHEMBL22658981 | 0.77 | JAK2 (0.36) | JAK2JAK1JAK3RETKDR | |
| SCHEMBL29407695 | 0.77 | JAK2 (0.36) | JAK2JAK1JAK3RETKDR | |
| SCHEMBL22658983 | 0.77 | JAK2 (0.36) | JAK2JAK1JAK3RETKDR | |
| SCHEMBL22658959 | 0.74 | LRRK2 (0.41) | DYRK1ALRRK2JAK2JAK1JAK3 | |
| SCHEMBL28700136 | 0.72 | LRRK2 (0.43) | DYRK1ALRRK2JAK2JAK1JAK3 | |
| SCHEMBL22675907 | 0.70 | FGFR1 (0.55) | DYRK1ALRRK2CYP3A4CYP2D6FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119874707-A | FGFR inhibitors and methods of use thereof | 传达治疗有限公司 | 2025-04-25 | — | — | CN | disclosed |
| CN-114126620-B | FGFR inhibitors and methods of use thereof | 传达治疗有限公司 | 2024-12-31 | — | — | CN | disclosed |
| EP-3968999-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | Relay Therapeutics, Inc. (US) | 2022-03-23 | — | — | EP | disclosed |
| CN-114126620-A | FGFR inhibitors and methods of use thereof | 传达治疗有限公司 | 2022-03-01 | — | — | CN | disclosed |