SCHEMBL29408024

SCHEMBL29408024

OC(c1cccnc1)c1ccc(-c2ccccc2)s1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.58
TSHR P16473 1/20 0.54
GAA P10253 1/20 0.47
MKNK1 Q9BUB5 1/20 0.47
MKNK2 Q9HBH9 1/20 0.47
CYP17A1 P05093 1/20 0.47
HSD17B2 P37059 2/20 0.45
CFTR P13569 1/20 0.45
SLC6A2 P23975 1/20 0.45
SLC6A4 P31645 1/20 0.45
SLC6A3 Q01959 1/20 0.45
GOPC Q9HD26 1/20 0.45
LMNA P02545 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
CYP2A6 P11509 4/20 0.44
CYP3A4 P08684 2/20 0.44
CYP2C9 P11712 2/20 0.44
CYP2C19 P33261 2/20 0.44
CYP2E1 P05181 1/20 0.44
CYP2D6 P10635 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7246231 0.84 TSHR (0.67) SMN1; SMN2TSHRGAACYP17A1CFTR
SCHEMBL10966428 0.75 SMN1; SMN2 (0.71) SMN1; SMN2TSHRGAACYP17A1CFTR
SCHEMBL9200850 0.75 CYP2A6 (0.66) SMN1; SMN2MKNK1MKNK2LMNACYP2A6
SCHEMBL30476552 0.75 SMN1; SMN2 (1.00) SMN1; SMN2TSHRGAACYP17A1CFTR
SCHEMBL28001042 0.75 SMN1; SMN2 (1.00) SMN1; SMN2TSHRGAACYP17A1CFTR
SCHEMBL477633 0.75 SMN1; SMN2 (1.00) SMN1; SMN2TSHRGAACYP17A1CFTR
SCHEMBL30476558 0.75 SMN1; SMN2 (1.00) SMN1; SMN2TSHRGAACYP17A1CFTR
SCHEMBL477393 0.75 SMN1; SMN2 (1.00) SMN1; SMN2TSHRGAACYP17A1CFTR
SCHEMBL10968928 0.74 SMN1; SMN2 (0.82) SMN1; SMN2TSHRGAAMKNK1MKNK2
SCHEMBL11071952 0.73 TSHR (0.54) SMN1; SMN2TSHRGAACYP17A1CFTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114127066-A Inhibitors of indoleamine 2, 3-dioxygenase and/or tryptophan 2, 3-dioxygenase 爱杜西亚药品有限公司 2022-03-01 CN disclosed