SCHEMBL29409508

SCHEMBL29409508

N#Cc1c(C(F)(F)F)cc(Cl)nc1Cl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 13/20 0.40
ALDH1A1 P00352 12/20 0.40
HPGD P15428 9/20 0.40
GAA P10253 9/20 0.40
GLA P06280 6/20 0.40
MEN1 O00255 3/20 0.40
KMT2A Q03164 3/20 0.40
LMNA P02545 3/20 0.40
HTT P42858 2/20 0.40
TP53 P04637 1/20 0.40
CRHBP P24387 1/20 0.40
CRHR2 Q13324 1/20 0.40
L3MBTL1 Q9Y468 6/20 0.39
TDP1 Q9NUW8 5/20 0.39
POLB P06746 2/20 0.38
MAPT P10636 1/20 0.38
AR P10275 2/20 0.37
HSD17B10 Q99714 1/20 0.36
NOTUM Q6P988 1/20 0.36
MAPK1 P28482 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1624009 1.00 KDM4E (0.40) KDM4EALDH1A1HPGDGAAGLA
SCHEMBL4193500 0.86 L3MBTL1 (0.36) KDM4EALDH1A1HPGDGAAGLA
SCHEMBL13374135 0.84 LMNA (0.39) KDM4EALDH1A1HPGDGAAGLA
SCHEMBL23860762 0.82 BACE1 (0.40) KDM4EALDH1A1HPGDGAAGLA
SCHEMBL29659097 0.82 L3MBTL1 (0.54) KDM4EALDH1A1HPGDGAAGLA
SCHEMBL23860828 0.82 KDM4E (0.40) KDM4EALDH1A1HPGDGAAGLA
SCHEMBL14967240 0.82 L3MBTL1 (0.54) KDM4EALDH1A1HPGDGAAGLA
SCHEMBL4191395 0.82 GLA (0.35) KDM4EALDH1A1HPGDGAAGLA
SCHEMBL13111414 0.80 KDM4E (0.44) KDM4EALDH1A1HPGDGAAGLA
SCHEMBL15111309 0.80 KDM4E (0.37) KDM4EALDH1A1HPGDGAAGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115611806-B Preparation method of 4-trifluoromethyl-3-cyanopyridine 江苏中旗科技股份有限公司 2024-11-19 CN claimed
CN-114149365-B Process control method for synthesizing 3-cyano-2, 6-dihydroxy-4-trifluoromethyl pyridine triethylamine salt 江苏中旗科技股份有限公司 2024-03-19 CN claimed
CN-117085700-A Preparation method and application method of special catalyst for dechlorination 西安凯立新材料股份有限公司 2023-11-21 CN claimed
CN-115611806-A Preparation method of 4-trifluoromethyl-3-cyanopyridine 江苏中旗科技股份有限公司 2023-01-17 CN claimed
CN-114149365-A Process control method for synthesizing 3-cyano-2, 6-dihydroxy-4-trifluoromethylpyridine triethylamine salt 江苏中旗科技股份有限公司 2022-03-08 CN claimed
CN-120247788-A Synthesis method of flonicamid intermediate 4-trifluoromethyl nicotinic acid 淮北龙溪生物科技有限公司 2025-07-04 CN disclosed
CN-114008036-B Disubstituted pyrazole compounds as ketohexokinase inhibitors 伊莱利利公司 2025-01-17 CN disclosed
CN-114667167-B Heterocyclic compounds for the treatment of cancer 阿提奥斯医药有限公司 2024-12-20 CN disclosed
CN-115611806-B Preparation method of 4-trifluoromethyl-3-cyanopyridine 江苏中旗科技股份有限公司 2024-11-19 CN disclosed
CN-115611806-B Preparation method of 4-trifluoromethyl-3-cyanopyridine 江苏中旗科技股份有限公司 2024-11-19 CN disclosed
CN-114149365-B Process control method for synthesizing 3-cyano-2, 6-dihydroxy-4-trifluoromethyl pyridine triethylamine salt 江苏中旗科技股份有限公司 2024-03-19 CN disclosed
CN-117658902-A Method for preparing 4-trifluoromethyl nicotinic acid 内蒙古源宏精细化工有限公司 2024-03-08 CN disclosed
CN-117164511-A Preparation method of 4-trifluoromethyl nicotinic acid 江西汇和化工有限公司 2023-12-05 CN disclosed
CN-117085700-A Preparation method and application method of special catalyst for dechlorination 西安凯立新材料股份有限公司 2023-11-21 CN disclosed
CN-115611806-A Preparation method of 4-trifluoromethyl-3-cyanopyridine 江苏中旗科技股份有限公司 2023-01-17 CN disclosed
CN-115611806-A Preparation method of 4-trifluoromethyl-3-cyanopyridine 江苏中旗科技股份有限公司 2023-01-17 CN disclosed
CN-114667167-A Heterocyclic compounds for the treatment of cancer 阿提奥斯医药有限公司 2022-06-24 CN disclosed
CN-114455557-A Method for recovering phosphorus oxychloride in chlorination reaction of hydroxyl compound 江苏中旗科技股份有限公司 2022-05-10 CN disclosed
EP-3983404-A1 DISUBSTITUTED PYRAZOLE COMPOUNDS AS KETOHEXOKINASE INHIBITORS ELI LILLY AND COMPANY (US) 2022-04-20 EP disclosed
CN-114149365-A Process control method for synthesizing 3-cyano-2, 6-dihydroxy-4-trifluoromethylpyridine triethylamine salt 江苏中旗科技股份有限公司 2022-03-08 CN disclosed