⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224112 | 0.74 | — | — | |
| SCHEMBL9124049 | 0.73 | — | — | |
| SCHEMBL12226 | 0.73 | — | — | |
| SCHEMBL27303540 | 0.70 | — | — | |
| SCHEMBL11945 | 0.65 | — | — | |
| SCHEMBL2345981 | 0.63 | — | — | |
| SCHEMBL18631 | 0.63 | — | — | |
| SCHEMBL14992401 | 0.61 | — | — | |
| SCHEMBL5342 | 0.61 | — | — | |
| SCHEMBL11304750 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004037827-A1 | SYNTHESIS OF SPIRO ORTHO ESTERS, SPIRO ORTHO CARBONATES, AND INTERMEDIATES | BIOAVAILABILITY SYSTEMS, LLC (US) | 2004-05-06 | — | — | WO | claimed |
| US-20040002611-A1 | Synthesis of spiro esters, spiro ortho carbonates, and intermediates | BIOAVAILABILITY SYSTEMS, LLC (US) | 2004-01-01 | — | — | US | claimed |
| US-6613918-B1 | Reacting an ester or carbonate with a tri C1-20 alkyl oxonium hexafluorophosphate; Bergaptols | BIOAVAILABILITY SYSTEMS, LLC | 2003-09-02 | — | — | US | claimed |
| CN-115677662-A | Indazole compound, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-115605479-A | Pyridoneopyrimidine derivative, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司（CN） | 2023-01-13 | — | — | CN | disclosed |
| CN-115448881-A | Heteroaryl compound, preparation method and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2022-12-09 | — | — | CN | disclosed |
| CN-115433127-A | Quinolinamines compound, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-12-06 | — | — | CN | disclosed |
| CN-115403595-A | Nitrogen-containing heterocyclic compound, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-115397815-A | Condensed bicyclic derivative, preparation method and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2022-11-25 | — | — | CN | disclosed |
| CN-115232131-A | Nitrogen-containing heterocyclic compound, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-10-25 | — | — | CN | disclosed |
| WO-2017220431-A1 | FUSED PYRAZOLE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2017-12-28 | — | — | WO | disclosed |
| CN-101679448-A | spiroindolinone derivatives | HOFFMANN LA ROCHE | 2010-03-24 | — | — | CN | disclosed |
| EP-2152714-A1 | SPIROINDOLINONE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-02-17 | — | — | EP | disclosed |
| US-7495007-B2 | Spiroindolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-02-24 | — | — | US | disclosed |
| EP-1996590-A1 | SPIROINDOLINONE DERIVATIVES | F. Hoffmann-la Roche AG (CH) | 2008-12-03 | — | — | EP | disclosed |
| WO-2008141975-A1 | SPIROINDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-27 | — | — | WO | disclosed |
| US-20080293723-A1 | SPIROINDOLINONE DERIVATIVES | LIU JIN-JUN | 2008-11-27 | — | — | US | disclosed |
| US-20080009486-A1 | SPIROINDOLINONE DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2008-01-10 | — | — | US | disclosed |
| WO-2007104664-A1 | SPIROINDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-20 | — | — | WO | disclosed |
| US-20070213341-A1 | Spiroindolinone derivatives | CHEN LI | 2007-09-13 | — | — | US | disclosed |