⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1223591 | 0.83 | — | — | |
| SCHEMBL10529106 | 0.73 | MEN1 (0.32) | — | |
| SCHEMBL294098 | 0.71 | — | — | |
| SCHEMBL96889 | 0.71 | — | — | |
| SCHEMBL11812103 | 0.71 | — | — | |
| SCHEMBL4512521 | 0.71 | — | — | |
| SCHEMBL823000 | 0.69 | — | — | |
| SCHEMBL10392633 | 0.69 | — | — | |
| SCHEMBL3210593 | 0.69 | — | — | |
| SCHEMBL22558204 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115433212-A | Biphenyl compound as immunomodulator and preparation method and application thereof | 深圳微芯生物科技股份有限公司 | 2022-12-06 | — | — | CN | claimed |
| CN-114698376-A | Biphenyl compound as immunomodulator, and preparation method and application thereof | 深圳微芯生物科技股份有限公司 | 2022-07-01 | — | — | CN | claimed |
| CN-114249726-A | Biphenyl compound, preparation method and application thereof | 深圳微芯生物科技股份有限公司 | 2022-03-29 | — | — | CN | claimed |
| US-20070282121-A1 | INTERMEDIATES FOR THE SYNTHESIS OF POLYPROPIONATE ANTIBIOTICS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-12-06 | — | — | US | claimed |
| US-7297807-B1 | Intermediates for the synthesis of polypropionate antibiotics | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2007-11-20 | — | — | US | claimed |
| WO-2004037827-A1 | SYNTHESIS OF SPIRO ORTHO ESTERS, SPIRO ORTHO CARBONATES, AND INTERMEDIATES | BIOAVAILABILITY SYSTEMS, LLC (US) | 2004-05-06 | — | — | WO | claimed |
| US-20040002611-A1 | Synthesis of spiro esters, spiro ortho carbonates, and intermediates | BIOAVAILABILITY SYSTEMS, LLC (US) | 2004-01-01 | — | — | US | claimed |
| US-6613918-B1 | Reacting an ester or carbonate with a tri C1-20 alkyl oxonium hexafluorophosphate; Bergaptols | BIOAVAILABILITY SYSTEMS, LLC | 2003-09-02 | — | — | US | claimed |
| CN-115433212-A | Biphenyl compound as immunomodulator and preparation method and application thereof | 深圳微芯生物科技股份有限公司 | 2022-12-06 | — | — | CN | disclosed |
| CN-114698376-B | Biphenyl compound as immunomodulator and preparation method and application thereof | 深圳微芯生物科技股份有限公司 | 2022-10-18 | — | — | CN | disclosed |
| CN-114698376-A | Biphenyl compound as immunomodulator, and preparation method and application thereof | 深圳微芯生物科技股份有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-114249726-A | Biphenyl compound, preparation method and application thereof | 深圳微芯生物科技股份有限公司 | 2022-03-29 | — | — | CN | disclosed |
| CN-113336673-A | Amantadine compound and preparation method and application thereof | 广东东阳光药业有限公司 | 2021-09-03 | — | — | CN | disclosed |
| CN-112469711-A | Synthesis method of quinoline derivative | 正大天晴药业集团股份有限公司 | 2021-03-09 | — | — | CN | disclosed |
| US-20020143024-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | PHARMACOPEIA, LLC | 2002-10-03 | — | — | US | disclosed |
| EP-1237888-A2 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-1094816-A4 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2001044239-A2 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB CO. (US) | 2001-06-21 | — | — | WO | disclosed |
| EP-1094816-A1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000001389-A1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB CO. (US) | 2000-01-13 | — | — | WO | disclosed |