Dronabinol

Dronabinol

SCHEMBL29410178

CCCCCc1cc(O)c2c(c1)OC(C)(C)C1CCC(C)=CC21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CNR1

The experimentally established mechanism targets of Dronabinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR1 known ✓ P21554 10/20 1.00
CNR2 P34972 16/20 1.00
ABHD12 Q8N2K0 3/20 1.00
ABHD6 Q9BV23 3/20 1.00
FAAH O00519 2/20 1.00
TRPM8 Q7Z2W7 2/20 1.00
GPR55 Q9Y2T6 2/20 1.00
NR1I2 O75469 1/20 1.00
LDHA P00338 1/20 1.00
GLRA1 P23415 1/20 1.00
GPR183 P32249 1/20 1.00
DRD3 P35462 1/20 1.00
ENPP2 Q13822 1/20 1.00
GPR18 Q14330 1/20 1.00
TRPA1 O75762 1/20 0.86
HTR1A P08908 1/20 0.86
TRPV1 Q8NER1 1/20 0.86
TRPV3 Q8NET8 1/20 0.86
TRPV6 Q9H1D0 1/20 0.86
TRPV4 Q9HBA0 1/20 0.86

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dronabinol SCHEMBL29390424 1.00 CNR2 (1.00) CNR2CNR1ABHD12ABHD6FAAH
Dronabinol SCHEMBL13394311 1.00 CNR2 (1.00) CNR2CNR1ABHD12ABHD6FAAH
Dronabinol SCHEMBL29349828 1.00 CNR2 (1.00) CNR2CNR1ABHD12ABHD6FAAH
Dronabinol SCHEMBL11375978 1.00 CNR2 (1.00) CNR2CNR1ABHD12ABHD6FAAH
Dronabinol SCHEMBL1227386 1.00 CNR2 (1.00) CNR2CNR1ABHD12ABHD6FAAH
Dronabinol SCHEMBL13214137 1.00 CNR2 (1.00) CNR2CNR1ABHD12ABHD6FAAH
Dronabinol SCHEMBL24702729 1.00 CNR2 (1.00) CNR2CNR1ABHD12ABHD6FAAH
Dronabinol SCHEMBL3686519 1.00 CNR2 (1.00) CNR2CNR1ABHD12ABHD6FAAH
Dronabinol SCHEMBL4609 1.00 CNR2 (1.00) CNR2CNR1ABHD12ABHD6FAAH
Dronabinol SCHEMBL22705549 1.00 CNR2 (1.00) CNR2CNR1ABHD12ABHD6FAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12514864-B2 Compositions and methods for oral administration of cannabinoids Natural Extraction Systems, LLC (US) 2026-01-06 US claimed
WO-2024194858-A1 EXTRACELLULAR VESICLES ASSOCIATED WITH CANNABINOID-LIPID CONJUGATES, METHODS FOR PRODUCING THE SAME AND USES THEREOF RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) 2024-09-26 WO claimed
US-20240269153-A1 BIOACTIVE BIPHASIC COMPOSITIONS NATURAL EXTRACTION SYS LLC (US) 2024-08-15 US claimed
EP-4038058-A1 CANNABINOID DERIVATIVES Canopy Growth Corporation (CA) 2022-08-10 EP claimed
EP-4734974-A1 CANNABINOID COMPOSITION FOR USE IN THE TREATMENT OF PAIN AND/OR INFLAMMATION Mabewo Phytopharm AG (CH) 2026-05-06 EP disclosed
US-20260083161-A1 CONTAINERS THAT CONTAIN ANIONIC CANNABINOIDS NATURAL EXTRACTION SYS LLC (US) 2026-03-26 US disclosed
US-20260069618-A1 CANNABINOID ACID ESTER COMPOSITIONS AND USES THEREOF EPM GROUP INC (US) 2026-03-12 US disclosed
US-12371412-B2 Methods of preparing cannabinoids or derivatives thereof FLORASCIENCE INC. (US) 2025-07-29 US disclosed
US-20250214957-A1 METHODS OF PREPARING CANNABINOIDS OR DERIVATIVES THEREOF FLORASCIENCE INC. 2025-07-03 US disclosed
EP-4565573-A1 CANNABINOID SYNTHESIS STARTING OUT FROM OLIVETOL AND TERPENE IN DICHLOROMETHANE WITH FeCl3 * 6H2O AS CATALYST Salud & Semillas, S.L. (ES) 2025-06-11 EP disclosed
WO-2025101898-A1 EMULSION COMPRISING AN ACTIVE COMPONENT, AND GUM ACACIA AND LECITHIN AS EMULSIFIERS BT DE Investments Inc. (US) 2025-05-15 WO disclosed
EP-4543230-A1 AEROSOLISABLE FORMULATION Nicoventures Trading Limited (GB) 2025-04-30 EP disclosed
WO-2022251709-A1 BIOACTIVE BIPHASIC COMPOSITIONS Natural Extraction Systems, LLC (US) 2022-12-01 WO disclosed
EP-4048253-A1 (-)-CIS TETRAHYDROCANNABINOL ((-)-CIS-THC) FOR USE AS A MEDICAMENT GW Research Limited (GB) 2022-08-31 EP disclosed
EP-4048254-A1 (+)-CIS TETRAHYDROCANNABINOL ((+)-CIS-THC) FOR USE AS A MEDICAMENT GW Research Limited (GB) 2022-08-31 EP disclosed
EP-4038058-A1 CANNABINOID DERIVATIVES Canopy Growth Corporation (CA) 2022-08-10 EP disclosed
EP-4017485-A1 CANNABINOID ACID ESTER COMPOSITIONS AND USES THEREOF EPM Group, Inc. (US) 2022-06-29 EP disclosed
WO-2022118303-A1 TRANSDERMAL PHARMACEUTICAL FORMULATIONS COMPRISING CBD OR THC FOR THE TREATMENT OF CANCER PIKE THERAPEUTICS, INC. (CA) 2022-06-09 WO disclosed
WO-2022091080-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF AUTISM SPECTRUM DISORDER SEACH SARID LTD. (IL) 2022-05-05 WO disclosed
CN-114207108-A Genetically modified host cells producing glycosylated cannabinoids 奥克塔林生物制剂公司 2022-03-18 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260069618-A1 CANNABINOID ACID ESTER COMPOSITIONS AND USES THEREOF CNR2, CNR1, IL17A CNR1 2/4885CNR2 1/4885ABHD12 2315/4885
US-20260083161-A1 CONTAINERS THAT CONTAIN ANIONIC CANNABINOIDS CNR2, CNR1, OPRD1 CNR1 2/4885CNR2 1/4885ABHD12 750/4885
US-20250214957-A1 METHODS OF PREPARING CANNABINOIDS OR DERIVATIVES THEREOF CNR2, CNR1, FAAH CNR1 2/4885CNR2 1/4885ABHD12 2158/4885
US-12371412-B2 Methods of preparing cannabinoids or derivatives thereof CNR2, CNR1, FAAH CNR1 2/4885CNR2 1/4885ABHD12 2158/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.