Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.33 |
| ▸ | RHEB | Q15382 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PDXK | O00764 | 1/20 | 0.32 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17979316 | 1.00 | NOTUM (0.37) | NOTUMRECQLPGK1MAPTENPP1 | |
| SCHEMBL19795354 | 0.87 | NPC1 (0.33) | RECQLMAPTNPC1POLBRAB9A | |
| SCHEMBL18018416 | 0.83 | PGK1 (0.39) | PGK1ENPP1KMOHDAC3HDAC1 | |
| SCHEMBL23363712 | 0.77 | NPC1 (0.47) | RECQLMAPTENPP1NPC1POLB | |
| SCHEMBL24487920 | 0.77 | ENPP1 (0.34) | PGK1ENPP1 | |
| SCHEMBL17979194 | 0.75 | SCN9A (0.34) | PGK1ENPP1CHRM5ALPL | |
| SCHEMBL17979054 | 0.74 | RECQL (0.36) | NOTUMRECQLMAPTPDXK | |
| SCHEMBL2303690 | 0.74 | PGK1 (0.36) | NOTUMPGK1ENPP1KMOCHRM5 | |
| SCHEMBL20642466 | 0.74 | PGK1 (0.36) | PGK1ENPP1KMOFFAR4 | |
| SCHEMBL30900398 | 0.74 | PGK1 (0.36) | NOTUMPGK1ENPP1KMOCHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109476640-B | Bicyclic proline compounds | 豪夫迈·罗氏有限公司 | 2022-02-25 | — | — | CN | disclosed |