Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.31 |
| ▸ | PDXK | O00764 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29411256 | 0.87 | NOTUM (0.37) | NPC1POLBRAB9AMAPTRECQL | |
| SCHEMBL17979316 | 0.87 | NOTUM (0.37) | NPC1POLBRAB9AMAPTRECQL | |
| SCHEMBL23363712 | 0.78 | NPC1 (0.47) | NPC1POLBRAB9AMAPTRECQL | |
| SCHEMBL18018416 | 0.74 | PGK1 (0.39) | — | |
| SCHEMBL19795353 | 0.72 | ALDH1A1 (0.33) | MAPT | |
| SCHEMBL30031898 | 0.71 | RECQL (0.36) | MAPTRECQLPDXK | |
| SCHEMBL17979054 | 0.71 | RECQL (0.36) | MAPTRECQLPDXK | |
| SCHEMBL17596004 | 0.70 | RECQL (0.41) | NPC1POLBRAB9ARECQLPDXK | |
| SCHEMBL903476 | 0.69 | PDXK (0.45) | NPC1POLBRAB9AMAPTRECQL | |
| SCHEMBL29416192 | 0.69 | PDXK (0.45) | NPC1POLBRAB9AMAPTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018015410-A1 | BICYCLIC PROLINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2018-01-25 | — | — | WO | disclosed |