Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLR1A | O95602 | 5/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.40 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25343849 | 1.00 | POLR1A (0.53) | POLR1AADRA2AADRA2BADRA2CMKNK2 | |
| SCHEMBL25345879 | 0.90 | POLR1A (0.42) | POLR1AADRA2AADRA2BADRA2CTGFBR1 | |
| SCHEMBL29412835 | 0.90 | POLR1A (0.42) | POLR1AADRA2AADRA2BADRA2CTGFBR1 | |
| SCHEMBL29412868 | 0.86 | KIT (0.46) | KITBRAF | |
| SCHEMBL25342226 | 0.86 | KIT (0.46) | KITBRAF | |
| SCHEMBL25345557 | 0.81 | MAPT (0.43) | KITBRAF | |
| SCHEMBL29412915 | 0.81 | MAPT (0.43) | KITBRAF | |
| SCHEMBL25342511 | 0.78 | DHODH (0.49) | — | |
| SCHEMBL29412850 | 0.78 | DHODH (0.49) | — | |
| SCHEMBL29412857 | 0.78 | DHODH (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022060799-A1 | COMPOUNDS WHICH INHIBIT RNA POLYMERASE AND THEIR USE | THE JOHNS HOPKINS UNIVERSITY (US) | 2022-03-24 | — | — | WO | disclosed |