Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 7/20 | 0.35 |
| ▸ | BRAF | P15056 | 7/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25345557 | 1.00 | MAPT (0.43) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL29412868 | 0.87 | KIT (0.46) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL25342226 | 0.87 | KIT (0.46) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL29412857 | 0.83 | DHODH (0.49) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL29412850 | 0.83 | DHODH (0.49) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL25342511 | 0.83 | DHODH (0.49) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL25343849 | 0.81 | POLR1A (0.53) | KITBRAF | |
| SCHEMBL29412873 | 0.81 | POLR1A (0.53) | KITBRAF | |
| SCHEMBL25345879 | 0.80 | POLR1A (0.42) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL29412835 | 0.80 | POLR1A (0.42) | MAPTMEN1KMT2ANPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022060799-A1 | COMPOUNDS WHICH INHIBIT RNA POLYMERASE AND THEIR USE | THE JOHNS HOPKINS UNIVERSITY (US) | 2022-03-24 | — | — | WO | disclosed |