SCHEMBL29414062

SCHEMBL29414062

COc1cc(-c2ccc(N)cc2)cc(OC)c1N

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.54
TDP1 Q9NUW8 4/20 0.54
CYP3A4 P08684 3/20 0.54
TSHR P16473 2/20 0.54
HSD17B10 Q99714 1/20 0.54
FYN P06241 1/20 0.49
TP53 P04637 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.47
MAPK1 P28482 2/20 0.44
CA1 P00915 2/20 0.44
CA2 P00918 2/20 0.44
CA12 O43570 1/20 0.44
CA9 Q16790 1/20 0.44
CYP19A1 P11511 5/20 0.44
GAA P10253 1/20 0.44
MAPT P10636 1/20 0.44
HTT P42858 1/20 0.44
NQO2 P16083 1/20 0.43
KIT P10721 1/20 0.42
APP P05067 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9323197 0.86 ALDH1A1 (0.54) ALDH1A1TDP1CYP3A4TSHRHSD17B10
SCHEMBL28681409 0.85 FYN (0.64) ALDH1A1TDP1CYP3A4TSHRHSD17B10
SCHEMBL30610431 0.83 ALDH1A1 (0.59) ALDH1A1TDP1CYP3A4TSHRHSD17B10
SCHEMBL7140279 0.83 ALDH1A1 (0.59) ALDH1A1TDP1CYP3A4TSHRHSD17B10
SCHEMBL649720 0.81 ALDH1A1 (0.83) ALDH1A1TDP1CYP3A4TSHRHSD17B10
SCHEMBL23630644 0.79 ALDH1A1 (0.55) ALDH1A1TDP1CYP3A4TSHRHSD17B10
Benzidine SCHEMBL28721485 0.78 TDP1 (0.69) ALDH1A1TDP1CYP3A4TSHRHSD17B10
SCHEMBL11695156 0.78 ALDH1A1 (0.53) ALDH1A1TDP1CYP3A4TSHRHSD17B10
SCHEMBL21084582 0.78 DYRK1A (0.63) ALDH1A1TDP1CYP3A4TSHRHSD17B10
SCHEMBL3793239 0.77 ALDH1A1 (0.57) ALDH1A1TDP1CYP3A4TSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114144522-A Methods for labeling and encoding pre-existing compound libraries X-化学有限公司 2022-03-04 CN disclosed