SCHEMBL29414652

SCHEMBL29414652

FC(F)(F)c1ccc(-c2nc(Cl)nc(-c3ccc(C(F)(F)F)cc3)n2)cc1

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 4/20 0.48
CASP3 P42574 2/20 0.46
S1PR1 P21453 5/20 0.45
S1PR3 Q99500 2/20 0.45
LMNA P02545 1/20 0.44
THRB P10828 1/20 0.44
DPP4 P27487 2/20 0.43
ADORA3 P0DMS8 1/20 0.43
GFER P55789 1/20 0.42
AHR P35869 1/20 0.41
HRH4 Q9H3N8 1/20 0.41
CHUK O15111 1/20 0.41
TXNRD1 Q16881 1/20 0.41
NOX4 Q9NPH5 1/20 0.41
SIRT2 Q8IXJ6 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22497605 0.96 KIF11 (0.48) KIF11CASP3S1PR1S1PR3LMNA
SCHEMBL30862210 0.89 KIF11 (0.58) KIF11S1PR1S1PR3LMNATHRB
SCHEMBL17269505 0.87 KIF11 (0.62) KIF11S1PR1LMNATHRBDPP4
SCHEMBL5217538 0.82 S1PR1 (0.51) KIF11CASP3S1PR1S1PR3LMNA
SCHEMBL28465080 0.81 KIF11 (0.71) KIF11S1PR1DPP4CHUKTXNRD1
SCHEMBL29712526 0.81 KIF11 (0.71) KIF11S1PR1DPP4CHUKTXNRD1
SCHEMBL783069 0.79 RAB9A (0.60) KIF11LMNA
SCHEMBL19041752 0.79 AHR (0.49) KIF11CASP3S1PR1S1PR3LMNA
SCHEMBL12311644 0.78 RAB9A (0.58) KIF11LMNA
SCHEMBL18538197 0.78 KIF11 (0.52) KIF11LMNATHRBDPP4ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111747933-B Substituted 1,3, 5-triazine compound, composition and application thereof 吉林省元合电子材料有限公司 2022-03-01 CN disclosed