Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30719637 | 0.73 | ATM (0.66) | LMNATSHRHSD17B10POLBKDM4E | |
| SCHEMBL4722654 | 0.73 | ATM (0.66) | LMNATSHRHSD17B10POLBKDM4E | |
| SCHEMBL2899875 | 0.72 | ATM (0.60) | BTKLMNAHSD17B10POLBKDM4E | |
| SCHEMBL29414785 | 0.69 | THRA (0.44) | TYMPNOTUMTHRATHRBGRIN1 | |
| SCHEMBL4354117 | 0.67 | MEN1 (0.54) | NOTUMLMNAHSD17B10POLBKDM4E | |
| SCHEMBL814784 | 0.65 | — | — | |
| SCHEMBL725368 | 0.65 | PDE3B (0.40) | TYMPNOTUMHSD17B10KDM4EXDH | |
| SCHEMBL8268404 | 0.63 | BTK (0.61) | TYMPNOTUMBTKRAB9AXDH | |
| SCHEMBL11685231 | 0.62 | ITK (0.49) | KDM4EHPGD | |
| SCHEMBL20247822 | 0.61 | NOTUM (0.36) | TYMPNOTUMPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3965884-A1 | MODULATORS OF THR-BETA AND METHODS OF USE THEREOF | Aligos Therapeutics, Inc. (US) | 2022-03-16 | — | — | EP | disclosed |