Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | BTK | Q06187 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALPL | P05186 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | TTK | P33981 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1065660 | 0.84 | ATM (0.56) | ATMNPSR1BTKHPGDNPC1 | |
| SCHEMBL29870198 | 0.75 | NPSR1 (1.00) | ATMNPSR1HPGDNPC1RAB9A | |
| SCHEMBL581143 | 0.75 | NPSR1 (1.00) | ATMNPSR1HPGDNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL2650936 | 0.75 | NPSR1 (0.65) | ATMNPSR1BTKHPGDNPC1 | |
| SCHEMBL4784523 | 0.74 | BTK (1.00) | ATMNPSR1BTKHPGDNPC1 | |
| SCHEMBL11169740 | 0.73 | MEN1 (0.65) | ATMNPSR1BTKHPGDNPC1 | |
| SCHEMBL11480060 | 0.73 | NPSR1 (0.63) | ATMNPSR1HPGDNPC1RAB9A | |
| SCHEMBL32670348 | 0.72 | ATM (0.52) | ATMNPSR1BTKHPGDNPC1 | |
| SCHEMBL29414701 | 0.72 | TYMP (0.47) | BTKHPGDRAB9AKDM4EHSD17B10 | |
| SCHEMBL3988734 | 0.72 | NPSR1 (0.61) | ATMNPSR1BTKHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217168-B2 | Azabicyclo [3. 1. 0] hexyl derivatives as modulators of dopamine D3 receptors | GLAXO GROUP LIMITED (GB) | 2012-07-10 | — | — | US | disclosed |
| EP-2205560-B1 | AZABICYCLO [3. 1. 0]HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LTD (GB) | 2011-12-28 | — | — | EP | disclosed |
| US-20100240661-A1 | AZABICYCLO [3. 1. 0] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2010-09-23 | — | — | US | disclosed |
| EP-2205560-A1 | AZABICYCLO Ý3. 1. 0¨HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | Glaxo Group Limited (GB) | 2010-07-14 | — | — | EP | disclosed |
| US-20090176773-A1 | Non-Peptidic Inhibitors of AKAP/PKA Interaction | FORSCHUNGSVERBUND BERLIN E.V. (DE) | 2009-07-09 | — | — | US | disclosed |
| US-20090176773-A1 | Non-Peptidic Inhibitors of AKAP/PKA Interaction | FORSCHUNGSVERBUND BERLIN E.V. (DE) | 2009-07-09 | — | — | US | disclosed |
| WO-2009043884-A1 | AZABICYCLO [3. 1. 0] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |
| US-6951858-B2 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2005-10-04 | — | — | US | disclosed |
| US-20050075339-A1 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2005-04-07 | — | — | US | disclosed |
| EP-1414808-A1 | 1,2,4-TRIAZIN-3,5-DIONES AS GONADOTROPIN-RELEASING HORMONE RECEPTOR (GNRH) ANTAGONISTS | Neurocrine Biosciences, Inc. (US) | 2004-05-06 | — | — | EP | disclosed |
| US-6673796-B2 | SEXUAL DISORDERS | NEUROCRINE BIOSCIENCES, INC. | 2004-01-06 | — | — | US | disclosed |
| US-20030114455-A1 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. | 2003-06-19 | — | — | US | disclosed |
| WO-2003011841-A1 | 1,2,4-TRIAZIN-3,5-DIONES AS GONADOTROPIN-RELEASING HORMONE RECEPTOR (GNRH) ANTAGONISTS | NEUROCRINE BIOSCIENCES, INC. (US) | 2003-02-13 | — | — | WO | disclosed |
| US-6303603-B1 | FOR THEARPY OF ANXIETY, DEPRESSION, SCHIZOPHRENIA | PIERRE FABRE MEDICAMENT (FR) | 2001-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114455-A1 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | GNRHR, GHRHR, LHCGR | ATM 4784/4885NPSR1 26/4885BTK 4152/4885 |
| US-20100240661-A1 | AZABICYCLO [3. 1. 0] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | DRD3, CHRNA5, NR3C2 | ATM 4544/4885NPSR1 63/4885BTK 3320/4885 |
| US-20090176773-A1 | Non-Peptidic Inhibitors of AKAP/PKA Interaction | PRKCH, AIP, PRKCE | ATM 2047/4885NPSR1 684/4885BTK 1860/4885 |
| US-20050075339-A1 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | GNRHR, LHCGR, GHRHR | ATM 4595/4885NPSR1 26/4885BTK 3771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.