Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.78 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.78 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | ALOX5 | P09917 | 8/20 | 0.67 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | PLK1 | P53350 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | UBE2N | P61088 | 1/20 | 0.63 |
| ▸ | HTR6 | P50406 | 3/20 | 0.57 |
| ▸ | FABP4 | P15090 | 1/20 | 0.56 |
| ▸ | TNF | P01375 | 1/20 | 0.55 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12748306 | 1.00 | AKR1C3 (0.78) | AKR1C3AKR1C1LMNASMN1; SMN2ALOX5 | |
| SCHEMBL13302218 | 0.90 | ALOX5 (0.68) | AKR1C3AKR1C1LMNASMN1; SMN2ALOX5 | |
| SCHEMBL948989 | 0.90 | AKR1C3 (0.83) | AKR1C3AKR1C1LMNASMN1; SMN2ALOX5 | |
| SCHEMBL12748630 | 0.89 | AKR1C3 (0.78) | AKR1C3AKR1C1LMNASMN1; SMN2ALOX5 | |
| SCHEMBL949348 | 0.89 | LMNA (0.82) | AKR1C3AKR1C1LMNASMN1; SMN2ALOX5 | |
| SCHEMBL30689046 | 0.88 | ALOX5 (0.65) | AKR1C3AKR1C1LMNASMN1; SMN2ALOX5 | |
| SCHEMBL22638205 | 0.88 | ALOX5 (0.65) | AKR1C3AKR1C1LMNASMN1; SMN2ALOX5 | |
| SCHEMBL1466532 | 0.87 | AKR1C3 (1.00) | AKR1C3AKR1C1LMNASMN1; SMN2ALOX5 | |
| SCHEMBL7828918 | 0.87 | ALOX5 (0.62) | AKR1C3AKR1C1LMNASMN1; SMN2ALOX5 | |
| SCHEMBL12748623 | 0.86 | AKR1C3 (0.78) | AKR1C3AKR1C1LMNASMN1; SMN2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3965884-A1 | MODULATORS OF THR-BETA AND METHODS OF USE THEREOF | Aligos Therapeutics, Inc. (US) | 2022-03-16 | — | — | EP | disclosed |