SCHEMBL2941709

SCHEMBL2941709

COc1ccc(Sc2nc(N)nc3c2ncn3CC2(O[C](COC(=O)OC(C)C)COC(=O)OC(C)C)CC2)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HK1 P19367 1/20 0.35
HKDC1 Q2TB90 1/20 0.35
CYP2C19 P33261 3/20 0.34
HSP90AA1 P07900 1/20 0.34
HSP90AB1 P08238 1/20 0.34
CYP1A2 P05177 3/20 0.33
SLC29A1 Q99808 2/20 0.33
ADORA2A P29274 1/20 0.33
DHFR P00374 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
CYP2D6 P10635 2/20 0.31
CYP2C9 P11712 2/20 0.31
HIF1A Q16665 2/20 0.31
TP53 P04637 1/20 0.31
CYP3A4 P08684 1/20 0.31
CDK5 Q00535 2/20 0.30
CDK5R1 Q15078 2/20 0.30
FAP Q12884 1/20 0.30
ALDH1A1 P00352 1/20 0.30
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2943049 0.89 CYP2C19 (0.34) HK1HKDC1CYP2C19HSP90AA1HSP90AB1
SCHEMBL2936424 0.89 HK1 (0.34) HK1HKDC1CYP2C19HSP90AA1HSP90AB1
SCHEMBL4279937 0.85 HK1 (0.35) HK1HKDC1CYP2C19HSP90AA1HSP90AB1
SCHEMBL3289946 0.85 HK1 (0.33) HK1HKDC1CYP2C19HSP90AA1HSP90AB1
SCHEMBL2942826 0.82 FAP (0.35) HK1HKDC1CYP2C19HSP90AA1HSP90AB1
SCHEMBL2995160 0.82 ADORA2A (0.35) HK1HKDC1CYP2C19HSP90AA1HSP90AB1
SCHEMBL2937081 0.79 HSP90AA1 (0.33) HK1HKDC1CYP2C19HSP90AA1HSP90AB1
SCHEMBL4266002 0.78 HK1 (0.34) HK1HKDC1CYP2C19HSP90AA1HSP90AB1
SCHEMBL2907738 0.78 HSP90AA1 (0.37) HK1HKDC1CYP2C19HSP90AA1HSP90AB1
SCHEMBL2911550 0.77 HK1 (0.32) HK1HKDC1CYP2C19HSP90AA1HSP90AB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1358198-B1 NOVEL ACYCLIC NUCLEOSIDE PHOSPHONATE DERIVATIVES, SALTS THEREOF AND PROCESS FOR THE PREPARATION OF THE SAME LG LIFE SCIENCES LTD (KR) 2010-08-25 EP claimed