Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 2/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | CTSE | P14091 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29417834 | 0.84 | GPR119 (0.43) | DDB1CRBNKDM4EMAPTTHRB | |
| SCHEMBL31197447 | 0.75 | DDB1 (0.45) | DDB1CRBNRECQLKDM4EMAPT | |
| SCHEMBL29417828 | 0.75 | RECQL (0.43) | DDB1CRBNRECQLKDM4EMAPT | |
| SCHEMBL20996019 | 0.72 | CTSD (0.47) | KDM4EMAPTTHRBGPR119PIK3CA | |
| SCHEMBL29417844 | 0.72 | CTSD (0.47) | KDM4EMAPTTHRBGPR119PIK3CA | |
| SCHEMBL31197474 | 0.72 | USP30 (0.43) | DDB1CRBNRECQLKDM4EMAPT | |
| SCHEMBL31197488 | 0.70 | DDB1 (0.42) | DDB1CRBNRECQLKDM4EMAPT | |
| SCHEMBL31197440 | 0.70 | DDB1 (0.45) | DDB1CRBNRECQLMAPTGPR119 | |
| SCHEMBL31585430 | 0.70 | DDB1 (0.53) | DDB1CRBNKDM4EMAPTTHRB | |
| SCHEMBL12524380 | 0.69 | GPR119 (0.58) | DDB1CRBNRECQLKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022051567-A1 | SUBSTITUTED PYRIDO[2,3-B]PYRAZINONES AND REUATED COMPOUNDS AND THEIR USE IN TREATING MEDICAU CONDITIONS | Ikena Oncology, Inc. (US) | 2022-03-10 | — | — | WO | disclosed |