⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL167723 | 0.72 | — | — | |
| Dimethyl Fumarate SCHEMBL41835 | 0.72 | NFE2L2 (1.00) | — | |
| Dimethyl Fumarate SCHEMBL11668350 | 0.72 | NFE2L2 (1.00) | — | |
| Dimethyl Maleate SCHEMBL75864 | 0.72 | NFE2L2 (1.00) | — | |
| Dimethyl Fumarate SCHEMBL41836 | 0.72 | NFE2L2 (1.00) | — | |
| Dimethyl Fumarate SCHEMBL28128958 | 0.72 | NFE2L2 (1.00) | — | |
| Dimethyl Maleate SCHEMBL27720952 | 0.72 | NFE2L2 (1.00) | — | |
| SCHEMBL8174404 | 0.69 | — | — | |
| SCHEMBL16196651 | 0.69 | — | — | |
| SCHEMBL131574 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 691 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8916573-B2 | Quinazoline-2,4-dione derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2014-12-23 | — | — | US | claimed |
| US-20140171425-A1 | QUINAZOLINE-2,4-DIONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD. (CH) | 2014-06-19 | — | — | US | claimed |
| EP-2742042-A1 | QUINAZOLINE-2,4-DIONE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2014-06-18 | — | — | EP | claimed |
| CN-103732593-A | Quinazoline-2,4-dione derivatives | ACTELION PHARMACEUTICALS LTD | 2014-04-16 | — | — | CN | claimed |
| US-20130202529-A1 | BENZTROPINE COMPOUNDS AND USES THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN (US) | 2013-08-08 | — | — | US | claimed |
| WO-2013021363-A1 | QUINAZOLINE-2,4-DIONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2013-02-14 | — | — | WO | claimed |
| US-20090318502-A1 | Pharmaceutical Compositions Comprising a Hypoglycemic Agent and Methods of Using Same | INTRANASAL THERAPEUTICS, INC. (US) | 2009-12-24 | — | — | US | claimed |
| US-20090105292-A9 | Glucocorticoid Receptor Modulator Compounds and Methods | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2009-04-23 | — | — | US | claimed |
| US-7514468-B2 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2009-04-07 | — | — | US | claimed |
| US-20080226559-A1 | Benztropine Compounds and Uses Thereof | GOVERNMENT OF THE USA,REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2008-09-18 | — | — | US | claimed |
| US-4689343-A | AGRICULTURE | BAYER AKTIENGESELLSCHAFT (DE) | 1987-08-25 | — | — | US | claimed |
| CN-86103278-A | The method for preparing heterocyclic amide derivative | — | 1986-12-17 | — | — | CN | claimed |
| US-4628060-A | Fungicidal tetrahydrothiopyran-3,5-dione derivatives, intermediate derivatives, compositions, and method of use therefor | BAYER AKTIENGESELLSCHAFT (DE) | 1986-12-09 | — | — | US | claimed |
| EP-0199543-A2 | Heterocyclic amide derivatives | ICI AMERICAS INC. (US) | 1986-10-29 | — | — | EP | claimed |
| CN-85108623-A | Preparation has the novel method of the heterocycleamide of medical active | — | 1986-07-30 | — | — | CN | claimed |
| US-4599350-A | PHYTOPATHOGENS | BAYER AKTIENGESELLSCHAFT (DE) | 1986-07-08 | — | — | US | claimed |
| EP-0179619-A1 | Heterocyclic amides | ICI AMERICAS INC. (US) | 1986-04-30 | — | — | EP | claimed |
| EP-0144895-A2 | Thiolan-2,4-dion-3-carboxamides | BAYER AG (DE) | 1985-06-19 | — | — | EP | claimed |
| EP-0126380-A1 | Substituted tetrahydrothiopyran-3,5-dione-4-carboxamide | BAYER AG (DE) | 1984-11-28 | — | — | EP | claimed |
| EP-0041021-A2 | Cyclopropane carboxylic acid derivatives, their preparation, their use against parasites in plants and animals, their compositions and their intermediates | ROUSSEL-UCLAF (FR) | 1981-12-02 | — | — | EP | claimed |