Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.44 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17223741 | 1.00 | PDPK1 (0.44) | PDPK1GDADCPSRENDHFR | |
| SCHEMBL4106056 | 0.79 | DYRK1A (0.50) | DYRK1A | |
| SCHEMBL4872319 | 0.79 | DYRK1A (0.33) | PDPK1DCPSRENDHFRDYRK1A | |
| SCHEMBL23889230 | 0.79 | DYRK1A (0.33) | DCPSRENDHFRDYRK1A | |
| SCHEMBL4838531 | 0.79 | DYRK1A (0.41) | DYRK1A | |
| SCHEMBL24175031 | 0.79 | NPY5R (0.46) | RENDYRK1A | |
| SCHEMBL20274839 | 0.79 | REN (0.41) | PDPK1GDADCPSRENDHFR | |
| SCHEMBL21727172 | 0.75 | DYRK1A (0.31) | RENDYRK1A | |
| SCHEMBL31745118 | 0.75 | PIK3CA (0.31) | DYRK1A | |
| SCHEMBL18194317 | 0.75 | CHUK (0.40) | RENDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114269749-B | 5H-pyrrolo [3,2-d ] pyrimidine-2, 4-diamino compounds and antibody conjugates thereof | 苏特罗生物制药公司 | 2024-10-01 | — | — | CN | disclosed |
| EP-4217348-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BeiGene, Ltd. (KY) | 2023-08-02 | — | — | EP | disclosed |
| CN-114269749-A | 5H-pyrrolo [3,2-d ] pyrimidine-2, 4-diamino compounds and antibody conjugates thereof | 苏特罗生物制药公司 | 2022-04-01 | — | — | CN | disclosed |
| WO-2022063106-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BEIGENE, LTD. (KY) | 2022-03-31 | — | — | WO | disclosed |
| CN-114206392-A | Immunomodulatory agent antibody drug conjugates and uses thereof | 苏特罗生物制药公司 | 2022-03-18 | — | — | CN | disclosed |