Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | MDM4 | O15151 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31498725 | 0.93 | MDM2 (0.38) | MDM2MDM4TP53BACE1ALDH1A1 | |
| SCHEMBL20819231 | 0.90 | CASP3 (0.44) | MDM2MDM4TP53MAPTCASP3 | |
| SCHEMBL20819232 | 0.90 | CASP3 (0.44) | MDM2MDM4TP53MAPTCASP3 | |
| SCHEMBL2641803 | 0.89 | BRD4 (0.41) | MDM2MDM4TP53BACE1ALDH1A1 | |
| SCHEMBL15106634 | 0.89 | BRD4 (0.41) | MDM2MDM4TP53BACE1ALDH1A1 | |
| SCHEMBL15182047 | 0.89 | BRD4 (0.41) | MDM2MDM4TP53BACE1ALDH1A1 | |
| SCHEMBL29424172 | 0.85 | CASP3 (0.39) | MDM4TP53ALDH1A1MAPTCASP3 | |
| SCHEMBL18591886 | 0.83 | MDM2 (0.38) | MDM2MDM4TP53BACE1ALDH1A1 | |
| SCHEMBL30410248 | 0.81 | ALDH1A1 (0.42) | MDM4TP53ALDH1A1MAPTCASP3 | |
| SCHEMBL25695323 | 0.81 | ALDH1A1 (0.42) | MDM4TP53ALDH1A1MAPTCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11267822-B2 | BET bromodomain protein degraders with cleavable linkers | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11267822-B2 | BET bromodomain protein degraders with cleavable linkers | BRD4, BET1, BRWD1 | MDM2 30/4885MDM4 714/4885TP53 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.