Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2942438 | 1.00 | LMNA (0.46) | LMNAALDH1A1MEN1KMT2ACCR2 | |
| SCHEMBL1802232 | 0.85 | LMNA (0.44) | LMNAALDH1A1MEN1KMT2ACCR2 | |
| SCHEMBL2942520 | 0.85 | CYP3A4 (0.58) | LMNAALDH1A1GAACYP3A4CYP2C19 | |
| SCHEMBL5669833 | 0.83 | LMNA (0.47) | LMNAALDH1A1MEN1KMT2ACCR2 | |
| SCHEMBL1800991 | 0.81 | LMNA (0.55) | LMNAALDH1A1MEN1KMT2AGAA | |
| SCHEMBL2938720 | 0.81 | LMNA (0.55) | LMNAALDH1A1MEN1KMT2AGAA | |
| SCHEMBL5669107 | 0.76 | CYP3A4 (0.35) | LMNAALDH1A1MEN1KMT2ACCR2 | |
| SCHEMBL2939660 | 0.75 | CCR2 (0.46) | LMNAALDH1A1MEN1KMT2ACCR2 | |
| SCHEMBL1801116 | 0.75 | CCR2 (0.46) | LMNAALDH1A1MEN1KMT2ACCR2 | |
| SCHEMBL2943403 | 0.75 | CYP2C19 (0.44) | MEN1KMT2AGAACYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730147-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4,5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | GRUENENTHAL GMBH (DE) | 2010-02-03 | — | — | EP | claimed |