Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | PDE2A | O00408 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.37 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.37 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26732910 | 1.00 | PARP1 (0.42) | PARP1POLBMAPTPDE2ASMN1; SMN2 | |
| SCHEMBL24076896 | 0.94 | MAPT (0.44) | PARP1POLBMAPTPDE2ASMN1; SMN2 | |
| SCHEMBL29426569 | 0.94 | MAPT (0.44) | PARP1POLBMAPTPDE2ASMN1; SMN2 | |
| SCHEMBL24076281 | 0.83 | POLB (0.40) | POLBMAPTPDE2ASMN1; SMN2PRMT5 | |
| SCHEMBL24076279 | 0.81 | POLB (0.42) | POLBMAPTSMN1; SMN2NOTUMPRMT5 | |
| SCHEMBL30451535 | 0.81 | MAPT (0.45) | PARP1MAPTPDE2ASMN1; SMN2HSD17B10 | |
| SCHEMBL26732593 | 0.81 | MAPT (0.45) | PARP1MAPTPDE2ASMN1; SMN2HSD17B10 | |
| SCHEMBL29875057 | 0.80 | POLB (0.44) | PARP1POLBMAPTTSHR | |
| SCHEMBL15723643 | 0.80 | MAP2K4 (0.52) | GSK3BKDM4EMAPK1MAP2K4MAPKAPK3 | |
| SCHEMBL16675888 | 0.80 | TRPA1 (0.51) | MAPTHSD17B10GSK3BMAPK1MAP2K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196125-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | Denali Therapeutics Inc. (US) | 2023-06-21 | — | — | EP | disclosed |
| CN-116261456-A | Compounds, compositions, and methods | 戴纳立制药公司 | 2023-06-13 | — | — | CN | disclosed |
| WO-2022036204-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2022-02-17 | — | — | WO | disclosed |