Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SCSF1RDRD2FLT1FLT3FLT4HTR1BHTR1DHTR1FKDRKITMETOPRD1OPRK1OPRM1PDGFRAPDGFRBRET
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 2/20 | 0.55 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL29359514 | 0.93 | CA4 (0.59) | CA4GPR84CA2CA1NFKB1 | |
| Malic Acid SCHEMBL6372959 | 0.81 | CA4 (0.57) | CA4GPR84CA2FFAR1CA1 | |
| Malic Acid SCHEMBL674352 | 0.79 | CA4 (0.55) | CA4GPR84CA2FFAR1CA1 | |
| Malic Acid SCHEMBL749592 | 0.79 | CA4 (0.55) | CA4GPR84CA2FFAR1CA1 | |
| Malic Acid SCHEMBL17710445 | 0.79 | CA4 (0.55) | CA4GPR84CA2FFAR1CA1 | |
| Tetrabuthylammonium SCHEMBL5874718 | 0.79 | CA4 (0.59) | CA4CA1NFKB1 | |
| Malic Acid SCHEMBL8437254 | 0.78 | CA4 (0.53) | CA4NFKB1 | |
| Cetrimonium SCHEMBL8437296 | 0.78 | CA4 (0.53) | CA4NFKB1 | |
| Malic Acid SCHEMBL8437735 | 0.78 | CA4 (0.53) | CA4NFKB1 | |
| Tetrabuthylammonium SCHEMBL9094612 | 0.77 | CA4 (0.57) | CA4CA1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4091578-B1 | METHOD FOR PRODUCING PLATE DENTURE | TOKUYAMA DENTAL CORP (JP) | 2024-10-09 | — | — | EP | disclosed |
| US-11857385-B2 | Method of producing plate denture, curable composition for stereolithography, and plate denture production kit | TOKUYAMA DENTAL CORPORATION (JP) | 2024-01-02 | — | — | US | disclosed |
| US-20230137898-A1 | METHOD OF PRODUCING PLATE DENTURE, CURABLE COMPOSITION FOR STEREOLITHOGRAPHY, AND PLATE DENTURE PRODUCTION KIT | TOKUYAMA DENTAL CORPORATION (JP) | 2023-05-04 | — | — | US | disclosed |
| EP-4091578-A1 | METHOD FOR PRODUCING PLATE DENTURE, CURABLE STEREOLITHOGRAPHIC COMPOSITION, AND PLATE DENTURE PRODUCTION KIT | Tokuyama Dental Corporation (JP) | 2022-11-23 | — | — | EP | disclosed |
| US-20220071746-A1 | DENTAL MILL BLANK WITH OPTIMIZED COLOR TONE | KURARAY NORITAKE DENTAL INC. (JP) | 2022-03-10 | — | — | US | disclosed |