Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SCSF1RDRD2FLT1FLT3FLT4HTR1BHTR1DHTR1FKDRKITMETOPRD1OPRK1OPRM1PDGFRAPDGFRBRET
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 2/20 | 0.55 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL674352 | 1.00 | CA4 (0.55) | CA4GPR84CA2FFAR1CA1 | |
| Malic Acid SCHEMBL511412 | 0.93 | CA4 (0.59) | CA4GPR84CA2CA1NFKB1 | |
| Dodecanoate SCHEMBL8712409 | 0.91 | CA4 (0.48) | CA4GPR84CA1NFKB1 | |
| (R)-3-Hydroxybutanoate SCHEMBL29878569 | 0.84 | GPR84 (0.46) | GPR84CA2CA1NFKB1 | |
| SCHEMBL27875072 | 0.83 | NAAA (0.41) | GPR84NFKB1 | |
| Malic Acid SCHEMBL6372959 | 0.81 | CA4 (0.57) | CA4GPR84CA2FFAR1CA1 | |
| SCHEMBL11171494 | 0.81 | GPR84 (0.53) | GPR84CA2FFAR1CA1NFKB1 | |
| SCHEMBL28482797 | 0.80 | NAAA (0.45) | GPR84 | |
| Malic Acid SCHEMBL17710445 | 0.79 | CA4 (0.55) | CA4GPR84CA2FFAR1CA1 | |
| Malic Acid SCHEMBL29428463 | 0.79 | CA4 (0.55) | CA4GPR84CA2FFAR1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4454052-A | A HALOGENATED HYDROCARBON, A POLYETHYLENE GLYCOL METHYL ETHER AND A PHOSPHITE ESTER, EPOXY COMPOUND, OR ORGANOTIN STABILIZER | HITACHI, LTD. (JP) | 1984-06-12 | — | — | US | claimed |
| JP-62018457-A | — | — | None | — | — | JP | disclosed |
| EP-4682199-A1 | MEMBER, AND SEMICONDUCTOR MANUFACTURING?RELATED DEVICE | Daikin Industries, Ltd. (JP) | 2026-01-21 | — | — | EP | disclosed |
| US-20260001999-A1 | HYDROPHILIC OIL REPELLENT POLYMER | SUMITOMO CHEMICAL CO (JP) | 2026-01-01 | — | — | US | disclosed |
| EP-4578894-A1 | HYDROPHILIC OIL REPELLENT POLYMER | Sumitomo Chemical Company, Limited (JP) | 2025-07-02 | — | — | EP | disclosed |
| EP-4578895-A1 | POLYMER, RESIN COMPOSITION, MOLDED BODY, AND POLYMER PRODUCTION METHOD | Sumitomo Chemical Company, Limited (JP) | 2025-07-02 | — | — | EP | disclosed |
| WO-2025126738-A1 | HEAT INSULATION SASH AND METHOD FOR MANUFACTURING SAME | 株式会社カネカ | 2025-06-19 | — | — | WO | disclosed |
| WO-2024257818-A1 | SILANE-MODIFIED HYDROGENATED BLOCK COPOLYMER, POLYMER COMPOSITION, AND CROSSLINKED PRODUCT | 日本ゼオン株式会社 | 2024-12-19 | — | — | WO | disclosed |
| WO-2023095825-A1 | VINYL CHLORIDE-BASED PASTE RESIN AND RESIN COMPOSITION FOR AUTOMOBILE UNDERCOATING | 株式会社カネカ | 2023-06-01 | — | — | WO | disclosed |
| WO-2021065941-A1 | RESIN COMPOSITION FOR MOLDING AND MOLDED ARTICLE | 積水化学工業株式会社 | 2021-04-08 | — | — | WO | disclosed |
| CN-1934187-A | Flame-retardant styrene resin composition | DAI ICHI KOGYO SEIYAKU CO LTD (JP) | 2007-03-21 | — | — | CN | disclosed |
| CN-1243067-C | Resin composition for water-based coating material | DAIKIN IND LTD (JP) | 2006-02-22 | — | — | CN | disclosed |
| EP-1066813-B1 | Dental adhesive composition | SHOFU KK (JP) | 2004-10-06 | — | — | EP | disclosed |
| CN-1501966-A | Resin composition for water-based coating material | 大金工业株式会社 | 2004-06-02 | — | — | CN | disclosed |
| US-6583197-B1 | Excellent sustained release of fluorine; free radical polymerizable unsaturated monomer having an acid group, acid-reactive fluoroaluminsilicate glass filler, water, solvent | KABUSHIKI KAISHA SHOFU (JP) | 2003-06-24 | — | — | US | disclosed |
| EP-1066813-A2 | Dental adhesive composition | KABUSHIKI KAISHA SHOFU (JP) | 2001-01-10 | — | — | EP | disclosed |
| US-5670657-A | DISULFIDE CYCLIC COMPOUND FOR PRECIOUS METAL ADHESIVES | KABUSHIKI KAISHA SHOFU (JP) | 1997-09-23 | — | — | US | disclosed |
| JP-S6218457-A | VINYLIDENE FLUORIDE POLYMER COMPOSITION | SHOWA DENKO KK | 1987-01-27 | — | — | JP | disclosed |
| EP-0032753-B1 | VINYL CHLORIDE RESIN COMPOSITION, METHOD FOR ITS PRODUCTION AND COMPOSITION CONTAINING IT | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1984-08-29 | — | — | EP | disclosed |
| US-4454052-A | A HALOGENATED HYDROCARBON, A POLYETHYLENE GLYCOL METHYL ETHER AND A PHOSPHITE ESTER, EPOXY COMPOUND, OR ORGANOTIN STABILIZER | HITACHI, LTD. (JP) | 1984-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260001999-A1 | HYDROPHILIC OIL REPELLENT POLYMER | CCR1, H1-3, CCR3 | CA4 3755/4885GPR84 659/4885CA2 3636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.