Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.31 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | NSD2 | O96028 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SNCA | P37840 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25324572 | 1.00 | CNR2 (0.35) | CNR2CNR1CACNA2D1CYP1B1KDM4E | |
| SCHEMBL6684572 | 0.80 | HTT (0.40) | CYP11B1CYP11B2ALDH1A1GAACYP3A4 | |
| SCHEMBL6741649 | 0.80 | HTT (0.40) | CYP11B1CYP11B2ALDH1A1GAACYP3A4 | |
| SCHEMBL30735341 | 0.79 | CYP11B1 (0.34) | CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL15353499 | 0.78 | PRNP (0.36) | CNR2CNR1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL2734713 | 0.74 | ALDH1A1 (0.47) | ALDH1A1GAACYP2C19 | |
| SCHEMBL506055 | 0.73 | ALDH1A1 (0.43) | CYP1B1KDM4EMAPTALDH1A1HPGD | |
| SCHEMBL29980279 | 0.73 | ALDH1A1 (0.43) | CYP1B1KDM4EMAPTALDH1A1HPGD | |
| SCHEMBL6745332 | 0.72 | MAPK1 (0.33) | CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL6742914 | 0.72 | MAPK1 (0.33) | CYP11B1CYP11B2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4216951-A1 | KRAS G12D INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2022066646-A1 | KRAS G12D INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-03-31 | — | — | WO | disclosed |