Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.30 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 2/20 | 0.30 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.30 |
| ▸ | COMT | P21964 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4834945 | 0.91 | KDM4E (0.35) | ALDH1A1PPARGMEN1KMT2A | |
| SCHEMBL6684572 | 0.83 | HTT (0.40) | CYP11B1CYP11B2HTTAOC3LMNA | |
| SCHEMBL6741649 | 0.83 | HTT (0.40) | CYP11B1CYP11B2HTTAOC3LMNA | |
| SCHEMBL6055262 | 0.81 | TRPA1 (0.39) | CYP11B1CYP11B2AOC3LMNAALDH1A1 | |
| SCHEMBL15353499 | 0.81 | PRNP (0.36) | CYP11B1CYP11B2AOC3LMNAALDH1A1 | |
| SCHEMBL25324572 | 0.79 | CNR2 (0.35) | CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL29428628 | 0.79 | CNR2 (0.35) | CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL6745332 | 0.79 | MAPK1 (0.33) | CYP11B1CYP11B2AOC3LMNATAS1R3 | |
| SCHEMBL6742914 | 0.79 | MAPK1 (0.33) | CYP11B1CYP11B2AOC3LMNATAS1R3 | |
| SCHEMBL237043 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4519259-A1 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS | Treeline Biosciences, Inc. (US) | 2025-03-12 | — | — | EP | disclosed |
| WO-2023215482-A1 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS | Treeline Biosciences, Inc. (US) | 2023-11-09 | — | — | WO | disclosed |