Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 3/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.37 |
| ▸ | RELA | Q04206 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22636874 | 1.00 | TDO2 (0.55) | TDO2KCNH2L3MBTL1MAPTNPC1 | |
| SCHEMBL22648115 | 0.81 | BRD4 (0.36) | TDO2L3MBTL1MAPTNPC1RAB9A | |
| SCHEMBL22637149 | 0.79 | TDO2 (0.51) | TDO2L3MBTL1MAPTALDH1A1LMNA | |
| SCHEMBL29430767 | 0.79 | TDO2 (0.51) | TDO2L3MBTL1MAPTALDH1A1LMNA | |
| SCHEMBL22636777 | 0.78 | TDO2 (0.36) | TDO2L3MBTL1MAPTLMNAMAPK1 | |
| SCHEMBL22637035 | 0.78 | BRD4 (0.37) | TDO2L3MBTL1MAPTMAPK1BRD4 | |
| SCHEMBL22648208 | 0.77 | KCNH2 (0.45) | TDO2KCNH2NPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL22636634 | 0.76 | KCNH2 (0.44) | TDO2KCNH2NPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL29430632 | 0.76 | KCNH2 (0.44) | TDO2KCNH2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22636714 | 0.75 | MAPK1 (0.44) | TDO2L3MBTL1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3966196-A1 | PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2022-03-16 | — | — | EP | disclosed |