SCHEMBL29433489

SCHEMBL29433489

c1ccc(-c2ccccc2C2CCCC2)cc1

nearest known ligand 0.60

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 1/20 0.60
BRD4 O60885 1/20 0.49
CYP11B2 P19099 3/20 0.45
ADRA2A P08913 1/20 0.45
ADRA1D P25100 1/20 0.45
ADRA1A P35348 1/20 0.45
PTPN5 P54829 4/20 0.44
PTPN2 P17706 1/20 0.43
CHRNB2 P17787 1/20 0.43
CHRNA4 P43681 1/20 0.43
GAA P10253 1/20 0.42
BCHE P06276 1/20 0.41
ACHE P22303 1/20 0.41
PTGDR2 Q9Y5Y4 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10789751 1.00 PTGS2 (0.60) PTGS2BRD4CYP11B2ADRA2AADRA1D
Cyclohexane SCHEMBL9787037 0.98 PTGS2 (0.63) PTGS2BRD4CYP11B2ADRA2AADRA1D
SCHEMBL28154893 0.98 PTGS2 (0.63) PTGS2BRD4CYP11B2ADRA2AADRA1D
SCHEMBL30407966 0.98 PTGS2 (0.63) PTGS2BRD4CYP11B2ADRA2AADRA1D
SCHEMBL60703 0.98 PTGS2 (0.63) PTGS2BRD4CYP11B2ADRA2AADRA1D
Benzene SCHEMBL27912155 0.98 PTGS2 (0.63) PTGS2BRD4CYP11B2ADRA2AADRA1D
Water SCHEMBL27498058 0.96 PTGS2 (0.61) PTGS2BRD4CYP11B2ADRA2AADRA1D
Phosphine SCHEMBL27888972 0.96 PTGS2 (0.61) PTGS2BRD4CYP11B2ADRA2AADRA1D
Hydrogen Sulfide SCHEMBL27800905 0.96 PTGS2 (0.61) PTGS2BRD4CYP11B2ADRA2AADRA1D
SCHEMBL28228917 0.96 PTGS2 (0.56) PTGS2BRD4CYP11B2ADRA2AADRA1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118742545-A Fused heterocyclic compounds as PI3K alpha inhibitors 南京征祥医药有限公司 2024-10-01 CN disclosed
CN-114008025-A ACSS2 inhibitors and methods of use thereof 美特波米德有限公司 2022-02-01 CN disclosed